Select a medication above to begin.
etodolac
generic
Black Box Warnings .
Cardiovascular Thrombotic Event
NSAIDs incr. risk of serious and potentially fatal cardiovascular thrombotic events, incl. MI and stroke; risk may occur early in tx and may incr. w/ duration of use; contraindicated in CABG periop setting
GI Bleeding, Ulceration, and Perforation
NSAIDs incr. risk of serious and potentially fatal GI adverse events incl. bleeding, ulcer, and stomach or intestine perforation; GI events may occur at any time during use and w/o warning sx; elderly pts and pts w/ hx of PUD or GI bleeding at greater risk for serious GI events
Adult Dosing .
Dosage forms: CAP: 200 mg, 300 mg; TAB: 400 mg, 500 mg; ER TAB: 400 mg, 500 mg, 600 mg
pain, mild-moderate
- [200-400 mg PO q6-8h]
- Max: 1000 mg/day; Info: use lowest effective dose, shortest effective tx duration; give w/ food if GI upset occurs
osteoarthritis
- [300-500 mg PO bid]
- Alt: 300 mg PO tid; 400-1000 mg ER PO qd; Max: 1000 mg/day; Info: use lowest effective dose, shortest effective tx duration; give w/ food if GI upset occurs
rheumatoid arthritis
- [300-500 mg PO bid]
- Alt: 300 mg PO tid; 400-1000 mg ER PO qd; Max: 1000 mg/day; Info: use lowest effective dose, shortest effective tx duration; give w/ food if GI upset occurs
for anti-inflammatory uses (off-label)
- [300 mg PO tid x7-14 days]
- Info: use lowest effective dose, shortest effective tx duration; give w/ food if GI upset occurs
renal dosing
- [see below]
- advanced renal dz: avoid use
- HD/PD: avoid use
hepatic dosing
- [no adjustment]
Peds Dosing .
- Dosage forms: ER TAB: 400 mg, 500 mg, 600 mg
juvenile idiopathic arthritis
- [6 yo and older, 20-30 kg]
- Dose: 400 mg PO qd; Info: give w/ food if GI upset occurs
- [6 yo and older, 31-45 kg]
- Dose: 600 mg PO qd; Info: give w/ food if GI upset occurs
- [6 yo and older, 46-60 kg]
- Dose: 800 mg PO qd; Info: give w/ food if GI upset occurs
- [6 yo and older, >60 kg]
- Dose: 1000 mg PO qd; Info: give w/ food if GI upset occurs
renal dosing
- [see below]
- advanced renal dz: avoid use
- HD/PD: avoid use
hepatic dosing
- [no adjustment]