Select a medication above to begin.
mefenamic acid
generic
Black Box Warnings .
Cardiovascular Thrombotic Event
NSAIDs incr. risk of serious and potentially fatal cardiovascular thrombotic events, incl. MI and stroke; risk may occur early in tx and may incr. w/ duration of use; contraindicated in CABG periop setting
GI Bleeding, Ulceration, and Perforation
NSAIDs incr. risk of serious and potentially fatal GI adverse events incl. bleeding, ulcer, and stomach or intestine perforation; GI events may occur at any time during use and w/o warning sx; elderly pts and pts w/ hx of PUD or GI bleeding at greater risk for serious GI events
Adult Dosing .
Dosage forms: CAP: 250 mg
pain, mild-moderate
- [250 mg PO q6h prn for up to 7 days]
- Start: 500 mg PO x1; Info: use lowest effective dose, shortest effective tx duration; give w/ food if GI upset occurs
dysmenorrhea
- [250 mg PO q6h prn for up to 3 days]
- Start: 500 mg PO x1; Info: use lowest effective dose, shortest effective tx duration; give w/ food if GI upset occurs
renal dosing
- [see below]
- CrCl >60: no adjustment; CrCl 50-60: not defined, caution advised; CrCl <50: avoid use; advanced renal dz: avoid use
- HD/PD: avoid use
hepatic dosing
- [see below]
- hepatic impairment: consider decr. usual dose
Peds Dosing .
- Dosage forms: CAP: 250 mg
pain, mild-moderate
- [14 yo and older]
- Dose: 250 mg PO q6h prn for up to 7 days; Start: 500 mg PO x1; Info: use lowest effective dose, shortest effective tx duration; give w/ food if GI upset occurs
renal dosing
- [see below]
- CrCl >60: no adjustment; CrCl 50-60: not defined, caution advised; CrCl <50: avoid use; advanced renal dz: avoid use
- HD/PD: avoid use
hepatic dosing
- [see below]
- hepatic impairment: consider decr. usual dose