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perindopril erbumine
generic
Black Box Warnings .
Fetal Toxicity
fetal/neonatal morbidity/mortality may occur when drugs that act directly on the renin-angiotensin system are used in pregnancy; D/C drug ASAP once pregnancy detected
Adult Dosing .
Dosage forms: TAB: 2 mg, 4 mg, 8 mg
HTN
- [4-16 mg/day PO divided qd-bid]
- Start: 4 mg PO qd; Max: 16 mg/day; Info: may divide start dose bid in elderly pts
cardiovascular event risk reduction
- [8 mg PO qd]
- Start: 4 mg PO qd x2wk; Info: for pts w/ stable CAD; in elderly pts, start 2 mg PO qd x1wk, then 4 mg PO qd x1wk
heart failure w/ reduced ejection fraction (off-label)
- [8-16 mg PO qd]
- Start: 2 mg PO qd, may incr. dose q1-2wk; Max: 16 mg/day
renal dosing
- [adjust dose amount]
- CrCl 30-89: start 2 mg qd, max 8 mg/day; CrCl <30: avoid use
- HD: start 2 mg qd, max 8 mg/day, on dialysis days admin. after dialysis; consider supplement if next maint. dose not due right after dialysis; PD: not defined
hepatic dosing
- [see below]
- hepatic impairment: not defined, caution advised
Peds Dosing .
Peds dosing is currently unavailable or not applicable for this drug.