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flurbiprofen
generic
Black Box Warnings .
Cardiovascular Thrombotic Event
NSAIDs incr. risk of serious and potentially fatal cardiovascular thrombotic events, incl. MI and stroke; risk may occur early in tx and may incr. w/ duration of use; contraindicated in CABG periop setting
GI Bleeding, Ulceration, and Perforation
NSAIDs incr. risk of serious and potentially fatal GI adverse events incl. bleeding, ulcer, and stomach or intestine perforation; GI events may occur at any time during use and w/o warning sx; elderly pts and pts w/ hx of PUD or GI bleeding at greater risk for serious GI events
Adult Dosing .
Dosage forms: TAB: 50 mg, 100 mg
rheumatoid arthritis
- [50-100 mg PO bid-tid]
- Max: 300 mg/day; Info: may give qid; use lowest effective dose, shortest effective tx duration; decr. dose in CYP2C9 poor metabolizers; give w/ food if GI upset occurs
osteoarthritis
- [50-100 mg PO bid-tid]
- Max: 300 mg/day; Info: may give qid; use lowest effective dose, shortest effective tx duration; decr. dose in CYP2C9 poor metabolizers; give w/ food if GI upset occurs
dysmenorrhea (off-label)
- [50-100 mg PO bid-tid]
- Start: 100 mg x1; Max: 300 mg/day; Info: may give qid; use lowest effective dose, shortest effective tx duration; decr. dose in CYP2C9 poor metabolizers; give w/ food if GI upset occurs
for anti-inflammatory uses (off-label)
- [50-100 mg PO bid-tid]
- Start: 100 mg x1; Max: 300 mg/day; Info: may give qid; use lowest effective dose, shortest effective tx duration; decr. dose in CYP2C9 poor metabolizers; give w/ food if GI upset occurs
pain, mild-moderate (off-label)
- [50-100 mg PO bid-tid]
- Start: 100 mg x1; Max: 300 mg/day; Info: may give qid; use lowest effective dose, shortest effective tx duration; decr. dose in CYP2C9 poor metabolizers; give w/ food if GI upset occurs
renal dosing
- [see below]
- moderate impairment: consider decr. usual dose; severe impairment: avoid use; Alt: consider decr. usual dose; advanced renal dz: avoid use
- HD/PD: avoid use
hepatic dosing
- [see below]
- hepatic impairment: consider decr. usual dose
Peds Dosing .
Peds dosing is currently unavailable or not applicable for this drug.