diphenhydramine

Adult Dosing .

Dosage forms:  CAP: 25 mg, 50 mg; TAB: 25 mg; SOL: 12.5 mg per 5 mL; INJ: 50 mg per mL

allergy sx

[25-50 mg PO/IM/IV q4-6h prn]

Max: 300 mg/day PO; 100 mg/dose up to 400 mg/day IM/IV

allergic rxns, mod-severe

[25-50 mg PO/IM/IV q2-4h prn]

Max: 300 mg/day PO; 100 mg/dose up to 400 mg/day IM/IV

extrapyramidal sx

[25-50 mg PO/IM/IV q6-8h prn]

Max: 300 mg/day PO; 100 mg/dose up to 400 mg/day IM/IV

insomnia, short-term tx

[25-50 mg PO qhs prn]

Start: 30min before bedtime

motion sickness prevention

[25-50 mg PO/IM/IV q4-6h prn]

Start: 30min before event; Max: 300 mg/day; 100 mg/dose up to 400 mg/day IM/IV

pruritus/urticaria

[25-50 mg PO/IM/IV q4-6h prn]

Max: 300 mg/day PO; 100 mg/dose up to 400 mg/day IM/IV

sedation

[25-50 mg PO/IM/IV q4-6h prn]

Max: 300 mg/day; 100 mg/dose up to 400 mg/day IM/IV

renal dosing

[no adjustment]

renal impairment: no adjustment

HD/PD: no adjustment; no supplement

hepatic dosing

[not defined]

Peds Dosing .

Dosage forms:  CAP: 25 mg, 50 mg; TAB: 25 mg; SOL: 12.5 mg per 5 mL; INJ: 50 mg per mL

allergy sx

[2-5 yo (off-label)]

Dose: 6.25 mg PO/IM/IV q4-6h prn; Max: 37.5 mg/day

[6-11 yo]

Dose: 12.5-25 mg PO/IM/IV q4-6h prn; Max: 150 mg/day

[12 yo and older]

Dose: 25-50 mg PO/IM/IV q4-6h prn; Max: 300 mg/day PO; 100 mg/dose up to 400 mg/day IM/IV

allergic rxns, mod-severe

[2-11 yo]

Dose: 1-2 mg/kg/dose PO/IM/IV q6h prn; Max: 50 mg/dose up to 300 mg/day

[12 yo and older]

Dose: 25-50 mg PO/IM/IV q2-4h prn; Max: 300 mg/day PO; 100 mg/dose up to 400 mg/day IM/IV

pruritus/urticaria

[2-5 yo (off-label)]

Dose: 6.25 mg PO/IM/IV q4-6h prn; Max: 37.5 mg/day

[6-11 yo]

Dose: 12.5-25 mg PO/IM/IV q4-6h prn; Max: 150 mg/day

[12 yo and older]

Dose: 25-50 mg PO/IM/IV q4-6h prn; Max: 300 mg/day PO; 100 mg/dose up to 400 mg/day IM/IV

extrapyramidal sx

[2-11 yo]

Dose: 1-2 mg/kg/dose PO/IM/IV q6-8h prn; Max: 50 mg/dose up to 300 mg/day

[12 yo and older]

Dose: 25-50 mg PO/IM/IV q6-8h prn; Max: 300 mg/day PO; 100 mg/dose up to 400 mg/day IM/IV

insomnia, short-term tx

[12 yo and older]

Dose: 25-50 mg PO qhs prn; Start: 30min before bedtime

motion sickness prevention

[2-5 yo]

Dose: 6.25 mg PO/IM/IV q4-6h prn; Start: 30min before event; Max: 37.5 mg/day

[6-11 yo]

Dose: 12.5-25 mg PO/IM/IV q4-6h prn; Start: 30min before event; Max: 150 mg/day

[12 yo and older]

Dose: 25-50 mg PO/IM/IV q4-6h prn; Start: 30min before event; Max: 300 mg/day

renal dosing

[no adjustment]

renal impairment: no adjustment

HD/PD: no adjustment; no supplement

hepatic dosing

[not defined]