Bicillin L-A

Adult Dosing .

Dosage forms:  INJ (pre-filled syringe): 600,000 units per mL

syphilis

[primary, secondary, or latent <1y]

Dose: 2.4 million units IM x1; Info: may repeat dose x1 after 1wk in pregnant pts; 1st-line agent

[latent >1y or unknown duration, or tertiary]

Dose: 2.4 million units IM qwk x3wk; Info: 1st-line agent

pharyngitis/tonsillitis, streptococcal

[1.2 million units IM x1]

rheumatic fever prophylaxis, secondary

[1.2 million units IM q4wk]

Info: may switch to q3wk if recurrent after q4wk regimen

renal dosing

[see below]

renal impairment: not defined, caution advised

HD/PD: not defined

hepatic dosing

[not defined]

Peds Dosing .

Dosage forms:  INJ (pre-filled syringe): 600,000 units per mL

syphilis, congenital

[neonates]

Dose: 50,000 units/kg/dose IM x1; Max: 2.4 million units/dose; Info: for asymptomatic dz; 1st-line agent

[infants/children]

Dose: 50,000 units/kg/dose IM qwk for up to 3wk; Max: 2.4 million units/dose; Info: for asymptomatic dz; 1st-line agent

syphilis, acquired

[primary or secondary or latent <1y, infants/children]

Dose: 50,000 units/kg/dose IM x1; Max: 2.4 million units/dose

[latent >1y or unknown duration, infants/children]

Dose: 50,000 units/kg/dose IM qwk x3wk; Max: 2.4 million units/dose

pharyngitis/tonsillitis, streptococcal

[<27 kg]

Dose: 0.6 million units IM x1

[>27 kg]

Dose: 1.2 million units IM x1

rheumatic fever prophylaxis, secondary

[<27 kg]

Dose: 0.6 million units IM q4wk; Info: may switch to q3wk if recurrent after q4wk regimen

[>27 kg]

Dose: 1.2 million units IM q4wk; Info: may switch to q3wk if recurrent after q4wk regimen

renal dosing

[see below]

renal impairment: not defined, caution advised

HD/PD: not defined

hepatic dosing

[not defined]