hydroxychloroquine sulfate

Adult Dosing .

Dosage forms:  TAB: 100 mg, 200 mg, 300 mg, 400 mg

Special Note

[strength clarification]

Info: 200 mg hydroxychloroquine sulfate = 155 mg hydroxychloroquine base; doses expressed as hydroxychloroquine sulfate

malaria prophylaxis

[400 mg PO qwk]

Start: 1-2wk before exposure; Info: give w/ food or milk; do not cut/crush/chew tab; D/C 4wk after exposure; see CDC Pre-Travel Malaria Prophylaxis recommendations in Guidelines > Specialties > Infectious Diseases

malaria tx

[800 mg PO x1, then 400 mg PO x1 at 6h, 24h, and 48h]

Info: give w/ food or milk; do not cut/crush/chew tab; to avoid relapse in acute P. vivax or P. ovale infection, follow up tx w/ primaquine or tafenoquine; refer to CDC guidelines

SLE

[200 mg PO qd or 400 mg/day PO divided qd-bid]

Info: give w/ food or milk; do not cut/crush/chew tab

rheumatoid arthritis

[200 mg PO qd or 400 mg/day PO divided qd-bid]

Start: 400-600 mg/day PO divided qd-bid x4-12wk; Info: give w/ food or milk; do not cut/crush/chew tab

renal dosing

[see below]

renal impairment: consider decr. usual dose

HD/PD: not defined

hepatic dosing

[see below]

hepatic impairment: consider decr. usual dose

Peds Dosing .

Dosage forms:  TAB: 100 mg, 200 mg, 300 mg, 400 mg

Special Note

[strength clarification]

Info: 6.5 mg/kg hydroxychloroquine sulfate = 5 mg/kg hydroxychloroquine base; doses expressed as hydroxychloroquine sulfate

malaria prophylaxis

[infants/children, >15 kg]

Dose: 6.5 mg/kg/dose PO qwk; Start: 1-2wk before exposure; Max: 400 mg/dose; Info: give w/ food or milk; do not cut/crush/chew tab; D/C 4wk after exposure; see CDC Pre-Travel Malaria Prophylaxis recommendations in Guidelines > Specialties > Infectious Diseases

malaria tx

[infants/children, >15 kg]

Dose: 13 mg/kg/dose PO x1, then 6.5 mg/kg/dose PO x1 at 6h, 24h, and 48h; Max: 800 mg for initial dose, 400 mg for subsequent doses; Info: give w/ food or milk; do not cut/crush/chew tab; to avoid relapse in acute P. vivax or P. ovale infection, follow up tx w/ primaquine or tafenoquine; refer to CDC guidelines

renal dosing

[see below]

renal impairment: consider decr. usual dose

HD/PD: not defined

hepatic dosing

[see below]

hepatic impairment: consider decr. usual dose