Nutropin AQ

Adult Dosing .

Dosage forms:  INJ (NuSpin pen): 5 mg per 2 mL, 10 mg per 2 mL, 20 mg per 2 mL

Special Note

[pen w/ cartridge strength clarification]

Info: 10 mg per 2 mL pen w/ cartridge delivers 0.1-4 mg doses in 0.1 mg increments; 20 mg per 2 mL pen w/ cartridge delivers 0.2-8 mg doses in 0.2 mg increments

[NuSpin pen strength clarification]

Info: 5 mg per 2 mL NuSpin pen delivers 0.05-1.75 mg doses in 0.05 mg increments; 10 mg per 2 mL NuSpin pen delivers 0.1-3.5 mg doses in 0.1 mg increments; 20 mg per 2 mL NuSpin pen delivers 0.2-7 mg doses in 0.2 mg increments

growth hormone deficiency

[0.006-0.025 mg/kg/dose SC qd]

Start: up to 0.006 mg/kg/dose SC qd; Max: 0.025 mg/kg/day in pts up to 35 yo, 0.0125 mg/kg/day in pts >35 yo; Alt: start 0.15-0.3 mg SC qd, incr. 0.1-0.2 mg/day q1-2mo; Info: for childhood- or adult-onset growth hormone deficiency; consider lower start dose/slower titration in elderly pts, non-weight-based dosing in obese pts

renal dosing

[not defined]

renal impairment: not defined

HD/PD: not defined

hepatic dosing

[not defined]

Peds Dosing .

Dosage forms:  INJ (NuSpin pen): 5 mg per 2 mL, 10 mg per 2 mL, 20 mg per 2 mL

Special Note

[pen w/ cartridge strength clarification]

Info: 10 mg per 2 mL pen w/ cartridge delivers 0.1-4 mg doses in 0.1 mg increments; 20 mg per 2 mL pen w/ cartridge delivers 0.2-8 mg doses in 0.2 mg increments

[NuSpin pen strength clarification]

Info: 5 mg per 2 mL NuSpin pen delivers 0.05-1.75 mg doses in 0.05 mg increments; 10 mg per 2 mL NuSpin pen delivers 0.1-3.5 mg doses in 0.1 mg increments; 20 mg per 2 mL NuSpin pen delivers 0.2-7 mg doses in 0.2 mg increments

growth hormone deficiency

[pre-pubertal pts]

Dose: up to 0.3 mg/kg/wk SC divided qd; Info: D/C when pt reaches satisfactory ht, epiphyses close, or no response

[pubertal pts]

Dose: up to 0.7 mg/kg/wk SC divided qd; Info: D/C when pt reaches satisfactory ht, epiphyses close, or no response

growth failure, CKD-assoc.

[up to 0.35 mg/kg/wk SC divided qd]

Info: may continue up to time of renal transplantation; see renal dosing below

short stature, Turner syndrome-assoc.

[up to 0.375 mg/kg/wk SC divided 3-7x/wk]

Info: D/C when pt reaches satisfactory ht, epiphyses close, or no response

idiopathic short stature

[up to 0.3 mg/kg/wk SC divided qd]

Info: D/C when pt reaches satisfactory ht, epiphyses close, or no response

renal dosing

[growth failure, CKD-assoc.]

CKD: no adjustment

HD: give usual dose qhs or 3-4h after dialysis; CCPD: give usual dose qam after dialysis; CAPD: give usual dose qpm at time of exchange

[all other indications]

renal impairment: not defined

HD/PD: not defined

hepatic dosing

[not defined]