haloperidol

Adult Dosing .

Dosage forms:  TAB: 0.5 mg, 1 mg, 2 mg, 5 mg, 10 mg, 20 mg

psychosis

[0.5-5 mg PO bid-tid]

Start: 0.5-2 mg PO bid-tid for moderate sx, 3-5 mg PO bid-tid for severe sx; Max: 100 mg/day for severe, refractory cases; Info: use lowest effective dose; taper dose gradually to D/C if long-term use; D/C if ANC <1000; consider D/C if unexplained decr. in WBC

Tourette syndrome

[0.5-5 mg PO bid-tid]

Start: 0.5-2 mg PO bid-tid; Max: 100 mg/day for severe, refractory cases; Info: use lowest effective dose; taper dose gradually to D/C if long-term use; D/C if ANC <1000; consider D/C if unexplained decr. in WBC

agitation, acute (off-label)

[0.5-10 mg PO q1-4h]

Max: 100 mg/day for severe, refractory cases; Info: use lowest effective dose; D/C if ANC <1000; consider D/C if unexplained decr. in WBC

refractory nausea/vomiting, chemo-related (off-label)

[0.5-2 mg PO q4-6h]

Info: use lowest effective dose; D/C if ANC <1000; consider D/C if unexplained decr. in WBC; search 'CINV' for epocrates Chemo-Induced Nausea & Vomiting in Adults decision tool

renal dosing

[no adjustment]

renal impairment: no adjustment

HD/PD: no adjustment; no supplement

hepatic dosing

[see below]

hepatic impairment: not defined, caution advised

Peds Dosing .

Dosage forms:  TAB: 0.5 mg, 1 mg, 2 mg, 5 mg, 10 mg, 20 mg

psychosis

[3-12 yo, 15-40 kg]

Dose: 0.05-0.15 mg/kg/day PO divided bid-tid; Start: 0.5 mg/day PO divided bid-tid, may incr. by 0.5 mg/day q5-7 days; Info: doses >6 mg/day rarely more effective; use lowest effective dose; taper dose gradually to D/C if long-term use; D/C if ANC <1000; consider D/C if unexplained decr. in WBC

[>12 yo]

Dose: 0.5-5 mg PO bid-tid; Start: 0.5-2 mg PO bid-tid for moderate sx, 3-5 mg bid-tid for severe sx; Max: 100 mg/day for severe, refractory cases; Info: use lowest effective dose; taper dose gradually to D/C if long-term use; D/C if ANC <1000; consider D/C if unexplained decr. in WBC

Tourette syndrome

[3-12 yo, 15-40 kg]

Dose: 0.05-0.075 mg/kg/day PO divided bid-tid; Start: 0.5 mg/day PO divided bid-tid, may incr. by 0.5 mg/day q5-7 days; Info: doses >6 mg/day rarely more effective; use lowest effective dose; taper dose gradually to D/C if long-term use; D/C if ANC <1000; consider D/C if unexplained decr. in WBC

[>12 yo]

Dose: 0.5-5 mg PO bid-tid; Start: 0.5-2 mg PO bid-tid; Max: 100 mg/day for severe, refractory cases; Info: use lowest effective dose; taper dose gradually to D/C if long-term use; D/C if ANC <1000; consider D/C if unexplained decr. in WBC

behavioral disorders, severe

[3-12 yo, 15-40 kg]

Dose: 0.05-0.075 mg/kg/day PO divided bid-tid; Start: 0.5 mg/day PO divided bid-tid, may incr. by 0.5 mg/day q5-7 days; Info: doses >6 mg/day rarely more effective; use lowest effective dose; taper dose gradually to D/C if long-term use; D/C if ANC <1000; consider D/C if unexplained decr. in WBC

[>12 yo]

Dose: 0.5-5 mg PO bid-tid; Max: 100 mg/day for severe, refractory cases; Info: use lowest effective dose; taper dose gradually to D/C if long-term use; D/C if ANC <1000; consider D/C if unexplained decr. in WBC

agitation (off-label)

[3-12 yo]

Dose: 0.01-0.03 mg/kg/day PO divided bid-tid; Max: 0.15 mg/kg/day; Info: use lowest effective dose; D/C if ANC <1000; consider D/C if unexplained decr. in WBC

[>12 yo]

Dose: 0.5-10 mg PO q1-4h; Max: 100 mg/day for severe, refractory cases; Info: use lowest effective dose; D/C if ANC <1000; consider D/C if unexplained decr. in WBC

renal dosing

[not defined]

renal impairment: consider adult renal dosing for guidance

HD/PD: consider adult renal dosing for guidance

hepatic dosing

[see below]

hepatic impairment: not defined, caution advised