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droperidol
generic
Black Box Warnings .
Proarrhythmic Effects
QT prolongation and/or torsades de pointes reported at or below recommended dose, some fatal cases, some pts w/o known QT prolongation risk factors; reserve for pts who fail tx alternatives; avoid use if prolonged baseline QT interval on 12-lead ECG; monitor ECG for arrhythmias prior to tx, continue x2-3h after tx completed; contraindicated if known/suspected QT prolongation incl. congenital long QT syndrome; use extreme caution if prolonged QT syndrome risk (CHF, bradycardia, diuretic use, cardiac hypertrophy, hypokalemia, hypomagnesemia, or in combo w/ drugs that prolong QT interval); other risk factors incl. >65yo, alcohol abuse, and use of benzodiazepines, volatile anesthetics, and IV opiates; initiate low dose, titrate w/ caution to desired effect
Adult Dosing .
Dosage forms: INJ: 2.5 mg per mL
nausea/vomiting prevention, postop
- [0.625-1.25 mg IV x1 at end of surgery]
- Max: 2.5 mg/initial dose; Alt: 0.625-1.25 mg IM x1 at end of surgery; Info: decr. initial dose in elderly, debilitated, or poor-risk pts; may give repeat doses w/ caution; rule out QT prolongation prior to use
cannabinoid hyperemesis syndrome, acute (off-label)
- [0.625-1.25 mg IV x1]
- Max: 2.5 mg/dose; Info: may give repeat doses w/ caution; rule out QT prolongation prior to use
renal dosing
- [see below]
- renal impairment: not defined, caution advised
- HD/PD: not defined, caution advised
hepatic dosing
- [see below]
- hepatic impairment: not defined, caution advised
Peds Dosing .
- Dosage forms: INJ: 2.5 mg per mL
nausea/vomiting prevention, postop
- [2-12 yo]
- Dose: 0.01-0.075 mg/kg/dose IV x1 at end of surgery; Max: 1.25 mg/dose; Alt: 0.01-0.075 mg/kg/dose IM x1 at end of surgery; Info: may give repeat doses w/ caution; rule out QT prolongation prior to use
renal dosing
- [see below]
- renal impairment: not defined, caution advised
- HD/PD: not defined, caution advised
hepatic dosing
- [see below]
- hepatic impairment: not defined, caution advised