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Paxil CR
paroxetine
Black Box Warnings .
Suicidality
antidepressants incr. suicidality risk in peds and young adult pts in short-term studies; monitor closely for clinical worsening and suicidality; advise families and caregivers of need for close observation and communication w/ prescriber; not approved for peds pts
Adult Dosing .
Dosage forms: ER TAB: 12.5 mg, 25 mg, 37.5 mg
major depressive disorder
- [25-62.5 mg PO qam]
- Start: 25 mg PO qam, may incr. by 12.5 mg/day qwk; Max: 62.5 mg/day; Info: start 12.5 mg PO qam, max 50 mg/day in elderly pts; do not crush/chew tab; taper dose gradually to D/C
panic disorder
- [12.5-75 mg PO qam]
- Start: 12.5 mg PO qam, may incr. by 12.5 mg/day qwk; Max: 75 mg/day; Info: max 50 mg/day in elderly pts; do not crush/chew tab; taper dose gradually to D/C
premenstrual dysphoric disorder
- [12.5-25 mg PO qam]
- Start: 12.5 mg PO qam, may incr. to 25 mg PO qam after 1wk; Max: 25 mg/day; Alt: 12.5-25 mg PO qam during luteal phase; Info: do not crush/chew tab; taper dose gradually to D/C
social anxiety disorder
- [12.5-37.5 mg PO qam]
- Start: 12.5 mg PO qam, may incr. by 12.5 mg/day qwk; Max: 37.5 mg/day; Info: do not crush/chew tab; taper dose gradually to D/C
vasomotor sx, mod-severe menopausal (off-label)
- [12.5-25 mg PO qd]
- Start: 12.5 mg PO qd, may incr. to 25 mg PO qd after at least 1wk; Info: do not crush/chew tab; taper dose gradually to D/C
renal dosing
- [adjust dose amount]
- severe impairment: start 12.5 mg ER qd; Info: max 50 mg/day ER if major depressive disorder or panic disorder use
- HD/PD: not defined
hepatic dosing
- [adjust dose amount]
- severe impairment: start 12.5 mg qd; Info: max 50 mg/day ER if major depressive disorder or panic disorder use
Peds Dosing .
Peds dosing is currently unavailable or not applicable for this drug.