Protonix

Adult Dosing .

Dosage forms:  DR TAB: 20 mg, 40 mg; DR GRANULE: 40 mg per pkt; INJ: various

GERD

[non-erosive, symptomatic (off-label)]

Dose: 40 mg PO qd x4-8wk; Alt: 40 mg IV qd; Info: IV form for short-term tx up to 10 days if unable to take oral regimen; do not cut/crush/chew tab or granules; give granules 30min before meals; see PPI Administration Alternatives table

[erosive esophagitis, short-term tx]

Dose: 40 mg PO qd x8-16wk; Alt: 40 mg IV qd; Info: IV form for short-term tx up to 10 days if unable to take oral regimen; do not cut/crush/chew tab or granules; give granules 30min before meals; see PPI Administration Alternatives table

[erosive esophagitis, maintenance tx]

Dose: 40 mg PO qd; Alt: 40 mg IV qd; Info: IV form for short-term tx up to 10 days if unable to take oral regimen; do not cut/crush/chew tab or granules; give granules 30min before meals; see PPI Administration Alternatives table

hypersecretory conditions

[individualize dose PO qd-bid]

Start: 40 mg PO bid; Alt: 80 mg IV q12h, may incr. dose to 80 mg IV q8h; Info: doses up to 240 mg/day have been used; do not cut/crush/chew tab or granules; give granules 30min before meals; see PPI Administration Alternatives table

upper GI bleeding (off-label)

[8 mg/h IV x72h]

Start: 80 mg IV x1

H. pylori infection (off-label)

[40-80 mg PO bid x14 days]

Info: part of multi-drug regimen, dosing may vary; do not cut/crush/chew tab or granules; give granules 30min before meals; see PPI Administration Alternatives table; search 'H. pylori Tx' for epocrates H. pylori Tx Regimens decision tool

renal dosing

[no adjustment]

renal impairment: no adjustment

HD/PD: no adjustment; no supplement

hepatic dosing

[no adjustment]

Peds Dosing .

Dosage forms:  DR TAB: 20 mg, 40 mg; DR GRANULE: 40 mg per pkt; INJ: various

GERD, erosive esophagitis

[IV form, 3-11 mo, <12.5 kg]

Dose: 0.8 mg/kg/dose IV qd; Info: for short-term tx up to 7 days if unable to take oral regimen; consider decr. dose in CYP2C19 poor metabolizers

[IV form, 3-11 mo, >12.5 kg]

Dose: 10 mg IV qd; Info: for short-term tx up to 7 days if unable to take oral regimen; consider decr. dose in CYP2C19 poor metabolizers

[IV form, 1-17 yo, <15 kg]

Dose: 10 mg IV qd; Info: for short-term tx up to 7 days if unable to take oral regimen; consider decr. dose in CYP2C19 poor metabolizers

[IV form, 1-17 yo, 15-40 kg]

Dose: 20 mg IV qd; Info: for short-term tx up to 7 days if unable to take oral regimen; consider decr. dose in CYP2C19 poor metabolizers

[IV form, 1-17 yo, >40 kg]

Dose: 40 mg IV qd; Info: for short-term tx up to 7 days if unable to take oral regimen; consider decr. dose in CYP2C19 poor metabolizers

[PO form, 5 yo and older, 15-39 kg]

Dose: 20 mg PO qd for up to 8wk; Info: consider decr. dose in CYP2C19 poor metabolizers; do not cut/crush/chew tab

[PO form, 5 yo and older, >40 kg]

Dose: 40 mg PO qd for up to 8wk; Info: consider decr. dose in CYP2C19 poor metabolizers; do not cut/crush/chew tab or granules; give granules 30min before meals; see PPI Administration Alternatives table

H. pylori infection (off-label)

[15-24 kg]

Dose: 40 mg PO bid x10-14 days; Info: part of multi-drug regimen; consider decr. dose in CYP2C19 poor metabolizers; do not cut/crush/chew tab or granules; give granules 30min before meals; see PPI Administration Alternatives table; search 'H. pylori Tx' for epocrates H. pylori Tx Regimens decision tool

[25-34 kg]

Dose: 60 mg PO bid x10-14 days; Info: part of multi-drug regimen; consider decr. dose in CYP2C19 poor metabolizers; do not cut/crush/chew tab or granules; give granules 30min before meals; see PPI Administration Alternatives table; search 'H. pylori Tx' for epocrates H. pylori Tx Regimens decision tool

[>35 kg]

Dose: 80 mg PO bid x10-14 days; Info: part of multi-drug regimen; consider decr. dose in CYP2C19 poor metabolizers; do not cut/crush/chew tab or granules; give granules 30min before meals; see PPI Administration Alternatives table; search 'H. pylori Tx' for epocrates H. pylori Tx Regimens decision tool

renal dosing

[no adjustment]

renal impairment: no adjustment

HD/PD: no adjustment; no supplement

hepatic dosing

[no adjustment]