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meloxicam
generic
Black Box Warnings .
Cardiovascular Thrombotic Event
NSAIDs incr. risk of serious and potentially fatal cardiovascular thrombotic events, incl. MI and stroke; risk may occur early in tx and may incr. w/ duration of use; contraindicated in CABG periop setting
GI Bleeding, Ulceration, and Perforation
NSAIDs incr. risk of serious and potentially fatal GI adverse events incl. bleeding, ulcer, and stomach or intestine perforation; GI events may occur at any time during use and w/o warning sx; elderly pts and pts w/ hx of PUD or GI bleeding at greater risk for serious GI events
Adult Dosing .
Dosage forms: CAP: 5 mg, 10 mg; TAB: 7.5 mg, 15 mg; SUSP: 7.5 mg per 5 mL
Special Note
- [formulation clarification]
- Info: meloxicam caps not interchangeable w/ tabs or oral susp; reassess dose if switching between oral forms
osteoarthritis
- [capsule form]
- Dose: 5-10 mg PO qd; Start: 5 mg PO qd; Max: 10 mg/day; Info: use lowest effective dose, shortest effective tx duration; consider lower dose in CYP2C9 poor metabolizers; give w/ food if GI upset occurs
- [tablet or suspension form]
- Dose: 7.5-15 mg PO qd; Start: 7.5 mg PO qd; Max: 15 mg/day; Info: use lowest effective dose, shortest effective tx duration; consider lower dose in CYP2C9 poor metabolizers; give w/ food if GI upset occurs
rheumatoid arthritis
- [tablet or suspension form]
- Dose: 7.5-15 mg PO qd; Start: 7.5 mg PO qd; Max: 15 mg/day; Info: use lowest effective dose, shortest effective tx duration; consider lower dose in CYP2C9 poor metabolizers; give w/ food if GI upset occurs
renal dosing
- [capsule form]
- severe impairment: avoid use
- HD: avoid use; Alt: max 5 mg/day; no supplement after dialysis; PD: avoid use
- [tablet or suspension form]
- severe impairment: avoid use
- HD: avoid use; Alt: max 7.5 mg/day; no supplement after dialysis; PD: avoid use
hepatic dosing
- [see below]
- Child-Pugh Class A or B: no adjustment; Child-Pugh Class C: not defined
Peds Dosing .
- Dosage forms: TAB: 7.5 mg, 15 mg; SUSP: 7.5 mg per 5 mL
Special Note
- [formulation clarification]
- Info: meloxicam caps not interchangeable w/ tabs or oral susp; reassess dose if switching between oral forms
juvenile idiopathic arthritis
- [2 yo and older]
- Dose: 0.125 mg/kg/dose PO qd; Max: 7.5 mg/day; Info: use lowest effective dose, shortest effective tx duration; consider lower dose in CYP2C9 poor metabolizers; give w/ food if GI upset occurs
renal dosing
- [see below]
- severe impairment: avoid use
- HD: avoid use; Alt: max 7.5 mg/day; no supplement after dialysis; PD: avoid use
hepatic dosing
- [see below]
- Child-Pugh Class A or B: no adjustment; Child-Pugh Class C: not defined