cefepime

Adult Dosing .

Dosage forms:  INJ

infections, bacterial

[1-2 g IV q8-12h]

Info: dose, duration varies w/ infection type, severity

pneumonia

[community-acquired]

Dose: 2 g IV q8h x7 days; Info: for inpatient tx; refer to IDSA guidelines

[hospital-acquired or ventilator-assoc.]

Dose: 2 g IV q8h x7 days; Info: may extend duration based on clinical response; refer to IDSA guidelines

febrile neutropenia

[2 g IV q8h until resolution of neutropenia]

Info: re-evaluate duration frequently if neutropenic >7 days

UTI

[mild-moderate]

Dose: 0.5-1 g IV q12h x7-10 days

[severe]

Dose: 2 g IV q12h x10 days

skin/skin structure infections, mod-severe uncomplicated

[2 g IV q12h x10 days]

intra-abdominal infections, complicated

[non-pseudomonal infections]

Dose: 2 g IV q12h x7-10 days; Info: give w/ metronidazole 500 mg PO/IV q6-8h

[pseudomonal infections]

Dose: 2 g IV q8h x7-10 days

meningitis, healthcare-associated (off-label)

[2 g IV q8h x10-14 days]

Info: may extend duration based on clinical and microbiologic response

resp. infections, cystic fibrosis pts (off-label)

[2 g IV q8h x14 days]

renal dosing

[if usual dose 500 mg q12h]

CrCl 11-60: 500 mg q24h; CrCl <11: 500 mg x1, then 250 mg q24h

HD: 1 g x1, then 500 mg q24h, on dialysis days admin. after dialysis; consider supplement if next maint. dose not due right after dialysis; PD: 500 mg q48h; supplement not defined

[if usual dose 1 g q12h]

CrCl 30-60: 1 g q24h; CrCl 11-29: 1 g x1, then 500 mg q24h; CrCl <11: 1 g x1, then 250 mg q24h

HD: 1 g x1, then 500 mg q24h, on dialysis days admin. after dialysis; consider supplement if next maint. dose not due right after dialysis; PD: 1 g q48h; supplement not defined

[if usual dose 2 g q12h]

CrCl 30-60: 2 g q24h; CrCl 11-29: 2 g x1, then 1 g q24h; CrCl <11: 2 g x1, then 500 mg q24h

HD: 1 g x1, then 500 mg q24h, on dialysis days admin. after dialysis; consider supplement if next maint. dose not due right after dialysis; PD: 2 g q48h; supplement not defined

[if usual dose 2 g q8h]

CrCl 30-60: 2 g q12h; CrCl 11-29: 2 g q24h; CrCl <11: 2 g x1, then 1 g q24h

HD: 1 g q24h, on dialysis days admin. after dialysis; consider supplement if next maint. dose not due right after dialysis; PD: 2 g q48h; supplement not defined

hepatic dosing

[no adjustment]

Peds Dosing .

Dosage forms:  INJ

infections, bacterial

[2 mo and older]

Dose: 50 mg/kg/dose IM/IV q8-12h; Max: 2 g/dose

pneumonia

[2 mo and older]

Dose: 50 mg/kg/dose IV q12h x10 days; Max: 2 g/dose; Info: give q8h if mod-severe pseudomonal infection

febrile neutropenia

[2 mo and older]

Dose: 50 mg/kg/dose IV q8h until resolution of neutropenia; Max: 2 g/dose; Info: re-evaluate duration frequently if neutropenic >7 days

UTI

[2 mo and older]

Dose: 50 mg/kg/dose IV q12h x7-10 days; Max: 2 g/dose

skin/skin structure infections, uncomplicated

[2 mo and older]

Dose: 50 mg/kg/dose IV q12h x10 days; Max: 2 g/dose

meningitis, healthcare-associated (off-label)

[2 mo and older]

Dose: 150 mg/kg/day IV divided q8h x10-14 days; Info: may extend duration based on clinical and microbiologic response

resp. infections, cystic fibrosis pts (off-label)

[2 mo and older]

Dose: 50 mg/kg/dose IV q8h x2wk; Max: 2 g/dose

renal dosing

[if usual dose 50 mg/kg/dose q12h]

CrCl 30-60: 50 mg/kg/dose q24h; CrCl 11-29: 50 mg/kg/dose x1, then 25 mg/kg/dose q24h; CrCl <11: 50 mg/kg/dose x1, then 12.5 mg/kg/dose q24h

HD: 25 mg/kg/dose x1, then 12.5 mg/kg/dose q24h, on dialysis days admin. after dialysis; consider supplement if next maint. dose not due right after dialysis; PD: 50 mg/kg/dose q48h; supplement not defined

[if usual dose 50 mg/kg/dose q8h]

CrCl 30-60: 50 mg/kg/dose q12h; CrCl 11-29: 50 mg/kg/dose q24h; CrCl <11: 50 mg/kg/dose x1, then 25 mg/kg/dose q24h

HD: 25 mg/kg/dose q24h, on dialysis days admin. after dialysis; consider supplement if next maint. dose not due right after dialysis; PD: 50 mg/kg/dose q48h; supplement not defined

hepatic dosing

[no adjustment]