zonisamide

Adult Dosing .

Dosage forms:  CAP: 25 mg, 50 mg, 100 mg

partial seizures

[100-600 mg/day PO divided qd-bid]

Start: 100 mg PO qd, may incr. by 100 mg/day q2wk; Max: 600 mg/day; Info: doses >400 mg/day rarely more effective; dose adjustment may be needed during pregnancy and/or postpartum; taper dose gradually to D/C

cyclic vomiting syndrome prophylaxis, moderate-severe (off-label)

[200-400 mg PO qd]

Start: 100 mg PO qd, incr. by 100 mg/day q2wk; Info: dose adjustment may be needed during pregnancy and/or postpartum; taper dose gradually to D/C

renal dosing

[see below]

CrCl <20: decr. usual dose by 35%; Info: caution advised, titrate slowly if renal impairment

HD: decr. usual dose by 50%, on dialysis days admin. after dialysis; consider giving 50% usual dose as supplement if next maint. dose not due right after dialysis; PD: decr. usual dose by 50%; supplement not defined

hepatic dosing

[see below]

hepatic impairment: not defined, caution advised; Info: titrate slowly

Peds Dosing .

Dosage forms:  CAP: 25 mg, 50 mg, 100 mg

partial seizures

[16 yo and older]

Dose: 100-600 mg/day PO divided qd-bid; Start: 100 mg PO qd, may incr. by 100 mg/day q2wk; Max: 600 mg/day; Info: doses >400 mg/day rarely more effective; dose adjustment may be needed during pregnancy and/or postpartum; taper dose gradually to D/C

renal dosing

[not defined]

CrCl <20: decr. usual dose by 35%; Info: caution advised, titrate slowly if renal impairment

HD: decr. usual dose by 50%, on dialysis days admin. after dialysis; consider giving 50% usual dose as supplement if next maint. dose not due right after dialysis; PD: decr. usual dose by 50%; supplement not defined

hepatic dosing

[see below]

hepatic impairment: not defined, caution advised; Info: titrate slowly