oxcarbazepine

Adult Dosing .

Dosage forms:  TAB: 150 mg, 300 mg, 600 mg; SUSP: 300 mg per 5 mL

partial seizures

[adjunct tx]

Dose: 600 mg PO bid; Start: 300 mg PO bid, incr. by up to 600 mg/day qwk; Max: 2400 mg/day; Info: dose adjustment may be needed during pregnancy and/or postpartum; taper dose gradually to D/C

[conversion to monotherapy]

Dose: 1200 mg PO bid; Start: 300 mg PO bid, incr. by up to 600 mg/day qwk; Max: 2400 mg/day; Info: D/C concomitant anticonvulsants over 3-6wk; dose adjustment may be needed during pregnancy and/or postpartum; taper dose gradually to D/C

[initial monotherapy]

Dose: 600 mg PO bid; Start: 300 mg PO bid, incr. by 300 mg/day q3 days; Max: 2400 mg/day; Info: dose adjustment may be needed during pregnancy and/or postpartum; taper dose gradually to D/C

trigeminal neuralgia (off-label)

[450-1200 mg PO bid]

Start: 300 mg PO bid, may incr. by 600 mg/day qwk; Info: dose adjustment may be needed during pregnancy and/or postpartum; taper dose gradually to D/C

bipolar disorder (off-label)

[600-1200 mg PO bid]

Start: 300 mg PO bid, incr. by 300 mg/day q3 days or by 600 mg/day qwk; Info: dose adjustment may be needed during pregnancy and/or postpartum; taper dose gradually to D/C

renal dosing

[adjust dose amount]

CrCl 10-50: may decr. usual dose by up to 25%; CrCl <10: decr. usual dose by 50%; Info: start 150 mg bid if CrCl <30; titrate dose slowly until response

HD: decr. usual dose by 50%, on dialysis days admin. after dialysis; supplement not defined; PD: decr. usual dose by 50%; supplement not defined

hepatic dosing

[see below]

mild-moderate impairment: no adjustment; severe impairment: not defined

Peds Dosing .

Dosage forms:  TAB: 150 mg, 300 mg, 600 mg; SUSP: 300 mg per 5 mL

partial seizures

[adjunct tx, 2-3 yo]

Dose: 60 mg/kg/day PO divided bid; Start: 8-10 mg/kg/day PO divided bid up to 600 mg/day, incr. dose over 2-4wk; Max: 60 mg/kg/day; Info: may start 16-20 mg/kg/day PO divided bid in pts <20 kg; taper dose gradually to D/C

[adjunct tx, 4-16 yo, 20-29 kg]

Dose: 450 mg PO bid; Start: 8-10 mg/kg/day PO divided bid up to 600 mg/day, incr. to target dose over 2wk; Info: taper dose gradually to D/C

[adjunct tx, 4-16 yo, 29.1-39 kg]

Dose: 600 mg PO bid; Start: 8-10 mg/kg/day PO divided bid up to 600 mg/day, incr. to target dose over 2wk; Info: taper dose gradually to D/C

[adjunct tx, 4-16 yo, >39 kg]

Dose: 900 mg PO bid; Start: 8-10 mg/kg/day PO divided bid up to 600 mg/day, incr. to target dose over 2wk; Info: taper dose gradually to D/C

[monotherapy, 4-16 yo, 20-24 kg]

Dose: 300-450 mg PO bid; Start: 8-10 mg/kg/day PO divided bid, incr. by 5 mg/kg/day q3 days if initial monotherapy or by up to 10 mg/kg/day qwk if conversion to monotherapy; Info: D/C concomitant anticonvulsants over 3-6wk; taper dose gradually to D/C

[monotherapy, 4-16 yo, 25-34 kg]

Dose: 450-600 mg PO bid; Start: 8-10 mg/kg/day PO divided bid, incr. by 5 mg/kg/day q3 days if initial monotherapy or by up to 10 mg/kg/day qwk if conversion to monotherapy; Info: D/C concomitant anticonvulsants over 3-6wk; taper dose gradually to D/C

[monotherapy, 4-16 yo, 35-44 kg]

Dose: 450-750 mg PO bid; Start: 8-10 mg/kg/day PO divided bid, incr. by 5 mg/kg/day q3 days if initial monotherapy or by up to 10 mg/kg/day qwk if conversion to monotherapy; Info: D/C concomitant anticonvulsants over 3-6wk; taper dose gradually to D/C

[monotherapy, 4-16 yo, 45-49 kg]

Dose: 600-750 mg PO bid; Start: 8-10 mg/kg/day PO divided bid, incr. by 5 mg/kg/day q3 days if initial monotherapy or by up to 10 mg/kg/day qwk if conversion to monotherapy; Info: D/C concomitant anticonvulsants over 3-6wk; taper dose gradually to D/C

[monotherapy, 4-16 yo, 50-59 kg]

Dose: 600-900 mg PO bid; Start: 8-10 mg/kg/day PO divided bid, incr. by 5 mg/kg/day q3 days if initial monotherapy or by up to 10 mg/kg/day qwk if conversion to monotherapy; Info: D/C concomitant anticonvulsants over 3-6wk; taper dose gradually to D/C

[monotherapy, 4-16 yo, 60-69 kg]

Dose: 600-1050 mg PO bid; Start: 8-10 mg/kg/day PO divided bid, incr. by 5 mg/kg/day q3 days if initial monotherapy or by up to 10 mg/kg/day qwk if conversion to monotherapy; Info: D/C concomitant anticonvulsants over 3-6wk; taper dose gradually to D/C

[monotherapy, 4-16 yo, >70 kg]

Dose: 750-1050 mg PO bid; Start: 8-10 mg/kg/day PO divided bid, incr. by 5 mg/kg/day q3 days if initial monotherapy or by up to 10 mg/kg/day qwk if conversion to monotherapy; Info: D/C concomitant anticonvulsants over 3-6wk; taper dose gradually to D/C

renal dosing

[adjust dose amount]

CrCl <30: decr. usual dose by 50%, max start dose 300 mg/24h

HD: decr. usual dose by 50%, on dialysis days admin. after dialysis; supplement not defined; PD: decr. usual dose by 50%; supplement not defined

hepatic dosing

[see below]

mild-moderate impairment: no adjustment; severe impairment: not defined