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phytonadione (vitamin K1)
generic
Black Box Warnings .
Severe Rxns (IV use)
severe rxns incl. death have occurred during and immediately after IV injection even w/ precautions to dilute injection and avoid rapid infusion; rxns resemble hypersensitivity or anaphylaxis incl. shock and cardiac and/or resp. arrest; may occur in pts w/ 1st vitamin K exposure; restrict IV route to cases where other routes not feasible and serious risk justified
Adult Dosing .
Dosage forms: TAB: 100 mcg, 500 mcg, 5 mg; INJ (pre-filled syringe): 1 mg per 0.5 mL; INJ (vial): 1 mg per 0.5 mL, 10 mg per mL
hypoprothrombinemia
- [vitamin K deficiency]
- Dose: 2.5-25 mg PO x1; Alt: 10 mg SC/IM/IV x1; Info: may repeat in 6-8h based on INR; subsequent doses and frequency based on INR
- [anticoagulant-induced]
- Dose: 2.5-10 mg PO x1; Alt: 1-10 mg SC/IM/IV x1; Info: may repeat PO dose in 12-48h or SC/IM/IV dose in 6-8h based on INR; subsequent doses and frequency based on INR
dietary supplementation
- [individualize dose]
- Info: see Dietary Reference Intakes: Vitamin K table
warfarin stabilization (off-label)
- [100 mcg PO qd-bid]
- Info: give w/ warfarin for pts on long-term tx w/ variable INR
renal dosing
- [not defined]
- renal impairment: not defined
- HD/PD: not defined
hepatic dosing
- [not defined]
Peds Dosing .
- Dosage forms: TAB: 100 mcg, 500 mcg, 5 mg; INJ (pre-filled syringe): 1 mg per 0.5 mL; INJ (vial): 1 mg per 0.5 mL, 10 mg per mL
neonatal hemorrhagic dz
- [prevention]
- Dose: 0.5-1 mg IM x1; Start: w/in 1h of birth; Info: may repeat dose in 6-8h
- [treatment]
- Dose: 1-2 mg SC/IM/IV x1; Info: higher doses may be necessary if mother on anticoagulant tx
dietary supplementation
- [individualize dose]
- Info: see Dietary Reference Intakes: Vitamin K table
hypoprothrombinemia (off-label)
- [vitamin K deficiency]
- Dose: 2.5-5 mg PO x1; Alt: 1-2 mg SC/IM/IV x1; Info: may repeat in 6-8h based on INR; subsequent doses and frequency based on INR
- [anticoagulant-induced]
- Dose: 0.5-5 mg PO x1; Alt: 0.5-5 mg SC/IM/IV x1; Info: may repeat PO dose in 12-48h or SC/IM/IV dose in 6-8h based on INR; subsequent doses and frequency based on INR
renal dosing
- [not defined]
- renal impairment: not defined
- HD/PD: not defined
hepatic dosing
- [not defined]