hydroxyurea

Adult Dosing .

Dosage forms:  CAP: 500 mg

Special Note

[uses, dosing may vary]

Info: refer to institution protocols and pkg insert prior to prescribing for uses, prophylactic meds, and dosing incl. toxicity-related dose adjustments; use lower of IBW or ABW for dose calculations

CML, refractory

[individualize dose PO qd]

Start: 15 mg/kg/dose PO qd; Info: do not open/crush/chew cap

squamous cell head/neck CA, locally advanced

[1000 mg PO q12h x11 doses on days 0-5 of 14-day cycle]

Start: 8-14h prior to initiation of XRT each cycle; Max: 7 cycles; Info: use w/ chemoradiation; do not open/crush/chew cap

sickle cell dz (off-label)

[15-35 mg/kg/dose PO qd]

Start: 15 mg/kg/dose PO qd; Max: 35 mg/kg/day; Info: for pts w/ sickle cell anemia w/ recurrent moderate to severe painful crises; titrate dose by 5 mg/kg/day q12wk to max tolerated dose while maint. neutrophils >2500, Plt >95,000, and Hgb >5.3 or if Hgb <9, reticulocytes >95,000; do not open/crush/chew cap

polycythemia vera (off-label)

[individualize dose PO qd]

Start: 500 mg PO bid; Info: titrate dose based on target Hct and hematologic toxicity; do not open/crush/chew cap

thrombocythemia, essential (off-label)

[individualize dose PO qd]

Start: 1500 mg PO qd; Info: titrate dose to maint. Plt <450,000; do not open/crush/chew cap

renal dosing

[adjust dose amount]

CrCl <60: decr. usual dose by 50%

HD: decr. usual dose by 50%, on dialysis days admin. after dialysis; no supplement; PD: decr. usual dose by 50%; no supplement

hepatic dosing

[not defined]

Peds Dosing .

Dosage forms:  CAP: 500 mg

Special Note

[uses, dosing may vary]

Info: refer to institution protocols and pkg insert prior to prescribing for uses, prophylactic meds, and dosing incl. toxicity-related dose adjustments; use lower of IBW or ABW for dose calculations

sickle cell dz (off-label)

[2 yo and older]

Dose: 20-35 mg/kg/dose PO qd; Start: 20 mg/kg/dose PO qd; Max: 35 mg/kg/day; Info: for pts w/ sickle cell anemia w/ recurrent moderate to severe painful crises; titrate dose by 5 mg/kg/day q8wk to max tolerated dose while maint. neutrophils >2000, Plt >80,000, and Hgb >5.3 or if Hgb <9, reticulocytes >80,000; do not open/crush/chew cap

renal dosing

[adjust dose amount]

CrCl <60: decr. usual dose by 50%

HD: decr. usual dose by 50%, on dialysis days admin. after dialysis; no supplement; PD: decr. usual dose by 50%; no supplement

hepatic dosing

[not defined]