TNKase

Adult Dosing .

Dosage forms:  INJ

STEMI

[<60 kg]

Dose: 30 mg IV x1; Start: ASAP from sx onset

[60-69 kg]

Dose: 35 mg IV x1; Start: ASAP from sx onset

[70-79 kg]

Dose: 40 mg IV x1; Start: ASAP from sx onset

[80-89 kg]

Dose: 45 mg IV x1; Start: ASAP from sx onset

[>90 kg]

Dose: 50 mg IV x1; Start: ASAP from sx onset

acute ischemic stroke

[<60 kg]

Dose: 15 mg IV x1; Start: ASAP w/in 3h of sx onset

[60-69 kg]

Dose: 17.5 mg IV x1; Start: ASAP w/in 3h of sx onset

[70-79 kg]

Dose: 20 mg IV x1; Start: ASAP w/in 3h of sx onset

[80-89 kg]

Dose: 22.5 mg IV x1; Start: ASAP w/in 3h of sx onset

[>90 kg]

Dose: 25 mg IV x1; Start: ASAP w/in 3h of sx onset

renal dosing

[not defined]

renal impairment: not defined

HD/PD: not defined

hepatic dosing

[see below]

mild-moderate impairment: not defined; severe impairment: not defined, caution advised

Peds Dosing .

Peds dosing is currently unavailable or not applicable for this drug.