Select a medication above to begin.
ibuprofen
generic
Black Box Warnings .
Cardiovascular Thrombotic Event
NSAIDs incr. risk of serious and potentially fatal cardiovascular thrombotic events, incl. MI and stroke; risk may occur early in tx and may incr. w/ duration of use; contraindicated in CABG periop setting
GI Bleeding, Ulceration, and Perforation
NSAIDs incr. risk of serious and potentially fatal GI adverse events incl. bleeding, ulcer, and stomach or intestine perforation; GI events may occur at any time during use and w/o warning sx; elderly pts and pts w/ hx of PUD or GI bleeding at greater risk for serious GI events
Adult Dosing .
Dosage forms: CAP: 200 mg; TAB: 100 mg, 200 mg, 400 mg, 600 mg, 800 mg; CHEWABLE: 50 mg, 100 mg; SUSP: 100 mg per 5 mL, 50 mg per 1.25 mL
osteoarthritis
- [300-800 mg PO tid-qid]
- Max: 3200 mg/day; Info: use lowest effective dose, shortest effective tx duration; give w/ food if GI upset occurs
rheumatoid arthritis
- [300-800 mg PO tid-qid]
- Max: 3200 mg/day; Info: use lowest effective dose, shortest effective tx duration; give w/ food if GI upset occurs
dysmenorrhea
- [400 mg PO q4h prn]
- Max: 3200 mg/day; Info: use lowest effective dose, shortest effective tx duration; give w/ food if GI upset occurs
pain, mild-moderate
- [400 mg PO q4-6h prn]
- Max: 3200 mg/day; Info: use lowest effective dose, shortest effective tx duration; give w/ food if GI upset occurs
fever
- [200-400 mg PO q4-6h prn]
- Max: 1200 mg/day; Info: use lowest effective dose, shortest effective tx duration; give w/ food if GI upset occurs
for anti-inflammatory uses (off-label)
- [400-800 mg PO q6-8h prn]
- Max: 3200 mg/day; Info: use lowest effective dose, shortest effective tx duration; give w/ food if GI upset occurs
renal dosing
- [see below]
- CrCl >60: no adjustment; CrCl 30-60: not defined, caution advised; CrCl <30: avoid use
- HD/PD: avoid use
hepatic dosing
- [see below]
- hepatic impairment: not defined, caution advised
Peds Dosing .
- Dosage forms: CAP: 200 mg; TAB: 100 mg, 200 mg, 400 mg, 600 mg, 800 mg; CHEWABLE: 50 mg, 100 mg; SUSP: 100 mg per 5 mL, 50 mg per 1.25 mL
fever
- [6 mo-11 yo]
- Dose: 5-10 mg/kg/dose PO q6-8h prn; Max: 40 mg/kg/day; Info: use lower dose for fever <102.5 F, higher dose for fever >102.5 F; use shortest effective tx duration; give w/ food if GI upset occurs
- [12 yo and older]
- Dose: 200-400 mg PO q4-6h prn; Max: 1200 mg/day; Info: use lowest effective dose, shortest effective tx duration; give w/ food if GI upset occurs
pain, mild-moderate
- [6 mo-11 yo]
- Dose: 5-10 mg/kg/dose PO q6-8h prn; Max: 40 mg/kg/day; Info: use lowest effective dose, shortest effective tx duration; give w/ food if GI upset occurs
- [12 yo and older]
- Dose: 400 mg PO q4-6h prn; Max: 2400 mg/day; Info: use lowest effective dose, shortest effective tx duration; give w/ food if GI upset occurs
juvenile idiopathic arthritis
- [30-40 mg/kg/day PO divided tid-qid]
- Max: 50 mg/kg/day; Info: use lowest effective dose, shortest effective tx duration; doses >40 mg/kg/day incr. risk of serious adverse events; give w/ food if GI upset occurs
renal dosing
- [see below]
- CrCl >60: no adjustment; CrCl 30-60: not defined, caution advised; CrCl <30: avoid use
- HD/PD: avoid use
hepatic dosing
- [see below]
- hepatic impairment: not defined, caution advised