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Tikosyn
dofetilide
Black Box Warnings .
Appropriate Use
pts starting or re-starting tx should be placed in facility that provides CrCl and continuous ECG monitoring and cardiac resuscitation for at least 3 days to minimize arrhythmia risk
Adult Dosing .
Dosage forms: CAP: 125 mcg, 250 mcg, 500 mcg
atrial fibrillation/flutter
- [500 mcg PO q12h]
- Info: for cardioversion and maintenance rhythm control; check QTc 2-3h after 1st dose, decr. dose to 250 mcg q12h if QTc >15% over baseline or >500 msec (>550 msec in pts w/ ventricular conduction abnormalities); D/C tx if QTc persistently >500 msec (>550 msec in pts w/ ventricular conduction abnormalities)
renal dosing
- [see below]
- CrCl 40-60: 250 mcg q12h; 125 mcg q12h if also QT prolongation; CrCl 20-39: 125 mcg q12h; 125 mcg q24h if also QT prolongation; CrCl <20: contraindicated
- HD/PD: not defined
hepatic dosing
- [see below]
- Child-Pugh Class A or B: no adjustment; Child-Pugh Class C: not defined
Peds Dosing .
Peds dosing is currently unavailable or not applicable for this drug.