esomeprazole

Adult Dosing .

Dosage forms:  DR CAP: 20 mg, 40 mg; DR GRANULE: 20 mg per pkt, 40 mg per pkt; INJ: various

GERD, non-erosive symptomatic

[20 mg PO qd x4-8wk]

Info: give >1h before meals; may open cap, see PPI Administration Alternatives table

erosive esophagitis

[initial tx]

Dose: 20-40 mg PO qd x4-16wk; Alt: 20-40 mg IV qd; Info: IV form for short-term tx up to 10 days if unable to take oral regimen; give PO form >1h before meals; may open cap, see PPI Administration Alternatives table

[maintenance tx]

Dose: 20 mg PO qd; Info: give >1h before meals; may open cap, see PPI Administration Alternatives table

H. pylori infection

[20-40 mg PO bid x14 days]

Info: part of multi-drug regimen, dosing may vary; give >1h before meals; may open cap, see PPI Administration Alternatives table; search 'H. pylori Tx' for epocrates H. pylori Tx Regimens decision tool

hypersecretory conditions

[individualize dose PO qd-bid]

Start: 40 mg PO bid; Info: doses up to 240 mg/day have been used; give >1h before meals; may open cap, see PPI Administration Alternatives table

gastric ulcer prophylaxis, NSAID-assoc.

[20-40 mg PO qd]

Info: give >1h before meals; may open cap, see PPI Administration Alternatives table

gastric/duodenal ulcer rebleeding prevention, post-endoscopy

[80 mg IV x1, then 8 mg/h IV x71.5h]

renal dosing

[see below]

renal impairment: no adjustment

HD/PD: not defined

hepatic dosing

[hypersecretory conditions]

Child-Pugh Class C: start 20 mg bid

[gastric/duodenal ulcer rebleeding prevention, post-endoscopy]

Child-Pugh Class A or B: max 6 mg/h; Child-Pugh Class C: max 4 mg/h

[all other indications]

Child-Pugh Class C: max 20 mg/day

Peds Dosing .

Dosage forms:  DR CAP: 20 mg, 40 mg; DR GRANULE: 2.5 mg per pkt, 5 mg per pkt, 10 mg per pkt, 20 mg per pkt, 40 mg per pkt; INJ: various

GERD, non-erosive symptomatic

[12 mo-11 yo]

Dose: 10 mg PO qd for up to 8wk; Info: give >1h before meals; see PPI Administration Alternatives table

[12-17 yo]

Dose: 20 mg PO qd x4wk; Info: give >1h before meals; may open cap, see PPI Administration Alternatives table

GERD, erosive esophagitis

[PO route, 1-11 mo, 3-5 kg]

Dose: 2.5 mg PO qd for up to 6wk; Info: give >1h before meals; see PPI Administration Alternatives table

[PO route, 1-11 mo, 5.1-7.5 kg]

Dose: 5 mg PO qd for up to 6wk; Info: give >1h before meals; see PPI Administration Alternatives table

[PO route, 1-11 mo, 7.6-12 kg]

Dose: 10 mg PO qd for up to 6wk; Info: give >1h before meals; see PPI Administration Alternatives table

[IV route, 1-11 mo]

Dose: 0.5 mg/kg/dose IV qd; Info: for short-term tx up to 10 days if unable to take oral regimen

erosive esophagitis

[PO route, 12 mo-11 yo, <20 kg]

Dose: 10 mg PO qd x8wk; Info: give >1h before meals; see PPI Administration Alternatives table

[PO route, 12 mo-11 yo, >20 kg]

Dose: 10-20 mg PO qd x8wk; Info: give >1h before meals; may open cap, see PPI Administration Alternatives table

[PO route, 12-17 yo]

Dose: 20-40 mg PO qd x4-8wk; Info: give >1h before meals; may open cap, see PPI Administration Alternatives table

[IV route, 12 mo-17 yo, <55 kg]

Dose: 10 mg IV qd; Info: for short-term tx up to 10 days if unable to take oral regimen

[IV route, 12 mo-17 yo, >55 kg]

Dose: 20 mg IV qd; Info: for short-term tx up to 10 days if unable to take oral regimen

H. pylori infection (off-label)

[15-24 kg]

Dose: 20 mg PO bid x10-14 days; Info: part of multi-drug regimen; give >1h before meals; may open cap, see PPI Administration Alternatives table; search 'H. pylori Tx' for epocrates H. pylori Tx Regimens decision tool

[25-34 kg]

Dose: 30 mg PO bid x10-14 days; Info: part of multi-drug regimen; give >1h before meals; may open cap, see PPI Administration Alternatives table; search 'H. pylori Tx' for epocrates H. pylori Tx Regimens decision tool

[>35 kg]

Dose: 40 mg PO bid x10-14 days; Info: part of multi-drug regimen; give >1h before meals; may open cap, see PPI Administration Alternatives table; search 'H. pylori Tx' for epocrates H. pylori Tx Regimens decision tool

renal dosing

[see below]

renal impairment: no adjustment

HD/PD: not defined

hepatic dosing

[not defined]

hepatic impairment: consider adult hepatic dosing for guidance