Select a medication above to begin.
indomethacin
generic
Black Box Warnings .
Cardiovascular Thrombotic Event
NSAIDs incr. risk of serious and potentially fatal cardiovascular thrombotic events, incl. MI and stroke; risk may occur early in tx and may incr. w/ duration of use; contraindicated in CABG periop setting
GI Bleeding, Ulceration, and Perforation
NSAIDs incr. risk of serious and potentially fatal GI adverse events incl. bleeding, ulcer, and stomach or intestine perforation; GI events may occur at any time during use and w/o warning sx; elderly pts and pts w/ hx of PUD or GI bleeding at greater risk for serious GI events
Adult Dosing .
Dosage forms: CAP: 25 mg, 50 mg; ER CAP: 75 mg; SUSP: 25 mg per 5 mL
osteoarthritis, moderate-severe
- [immediate-release form]
- Dose: 25 mg PO bid-tid; Max: 100 mg/dose, 200 mg/day; Info: may incr. dose by 25-50 mg/day qwk; use lowest effective dose, shortest effective tx duration; give w/ food if GI upset occurs
- [extended-release form]
- Dose: 75 mg ER PO qd-bid; Start: 75 mg ER PO qd; Info: use lowest effective dose, shortest effective tx duration; give w/ food if GI upset occurs
gout, acute
- [50 mg PO tid]
- Info: use lowest effective dose, shortest effective tx duration; give w/ food if GI upset occurs
bursitis/tendinitis, acute
- [immediate-release form]
- Dose: 75-150 mg/day PO divided tid-qid x7-14 days; Info: use lowest effective dose, shortest effective tx duration; give w/ food if GI upset occurs
- [extended-release form]
- Dose: 75 mg ER PO qd-bid x7-14 days; Info: use lowest effective dose, shortest effective tx duration; give w/ food if GI upset occurs
ankylosing spondylitis, moderate-severe
- [immediate-release form]
- Dose: 25 mg PO bid-tid; Max: 100 mg/dose, 200 mg/day; Info: may incr. dose by 25-50 mg/day qwk; use lowest effective dose, shortest effective tx duration; give w/ food if GI upset occurs
- [extended-release form]
- Dose: 75 mg ER PO qd-bid; Start: 75 mg ER PO qd; Info: use lowest effective dose, shortest effective tx duration; give w/ food if GI upset occurs
rheumatoid arthritis, moderate-severe
- [immediate-release form]
- Dose: 25 mg PO bid-tid; Max: 100 mg/dose, 200 mg/day; Info: may incr. dose by 25-50 mg/day qwk or by 25-50 mg/day qd if acute flare; use lowest effective dose, shortest effective tx duration; give w/ food if GI upset occurs
- [extended-release form]
- Dose: 75 mg ER PO qd-bid; Start: 75 mg ER PO qd; Info: use lowest effective dose, shortest effective tx duration; give w/ food if GI upset occurs
renal dosing
- [see below]
- CrCl >60: no adjustment; CrCl 30-60: not defined, caution advised; CrCl <30: avoid use
- HD/PD: avoid use
hepatic dosing
- [not defined]
Peds Dosing .
- Dosage forms: CAP: 25 mg, 50 mg; ER CAP: 75 mg; SUSP: 25 mg per 5 mL; INJ: various
patent ductus arteriosus
- [<48 h old]
- Dose: 0.2 mg/kg/dose IV x1, then 0.1 mg/kg/dose q12-24h x2 doses
- [2-7 days old]
- Dose: 0.2 mg/kg/dose IV x1, then 0.2 mg/kg/dose q12-24h x2 doses
- [>7 days old]
- Dose: 0.2 mg/kg/dose IV x1, then 0.25 mg/kg/dose q12-24h x2 doses
juvenile idiopathic arthritis
- [immediate-release form, 2-14 yo (off-label)]
- Dose: 1-2 mg/kg/day PO divided bid-qid; Max: 4 mg/kg/day up to 200 mg/day; Info: use lowest effective dose, shortest effective tx duration; give w/ food if GI upset occurs
- [immediate-release form, 15 yo and older]
- Dose: 1-2 mg/kg/day PO divided bid-qid; Max: 4 mg/kg/day up to 200 mg/day; Info: use lowest effective dose, shortest effective tx duration; give w/ food if GI upset occurs
- [extended-release form, 15 yo and older]
- Dose: 75 mg ER PO qd-bid; Start: 75 mg ER PO qd; Max: 150 mg/day ER; Info: use lowest effective dose, shortest effective tx duration; give w/ food if GI upset occurs
renal dosing
- [patent ductus arteriosus]
- significant impairment/anuria: contraindicated
- HD/PD: avoid use
- [juvenile idiopathic arthritis]
- CrCl >60: no adjustment; CrCl 30-60: not defined, caution advised; CrCl <30: avoid use
- HD/PD: avoid use
hepatic dosing
- [not defined]