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Methylin
methylphenidate
Black Box Warnings .
Abuse, Misuse, and Addiction
CNS stimulants have high potential for abuse and misuse, can lead to substance use disorder, incl. addiction; misuse and abuse can result in overdose and death, risk incr. w/ higher doses or unapproved admin. methods; assess risk for abuse, misuse, and addiction before prescribing and throughout tx; educate pts and families about risks and proper drug storage and disposal; monitor frequently for s/sx of abuse, misuse, and addiction during tx
Adult Dosing .
Dosage forms: SOL: 5 mg per 5 mL, 10 mg per 5 mL
Special Note
- [strength clarification]
- Info: all strengths expressed as methylphenidate hydrochloride
ADHD
- [10-60 mg/day PO divided bid-tid]
- Start: 5-10 mg PO bid, may incr. by 5-10 mg/day q7 days; Max: 60 mg/day; Info: duration 3-5h; give 30-45min before meals, last dose before 6pm
narcolepsy
- [10-60 mg/day PO divided bid-tid]
- Start: 5-10 mg PO bid, may incr. by 5-10 mg/day q7 days; Max: 60 mg/day; Info: give 30-45min before meals, last dose before 6pm
renal dosing
- [not defined]
- renal impairment: not defined
- HD/PD: not defined
hepatic dosing
- [not defined]
Peds Dosing .
- Dosage forms: SOL: 5 mg per 5 mL, 10 mg per 5 mL
Special Note
- [strength clarification]
- Info: all strengths expressed as methylphenidate hydrochloride
ADHD
- [4-5 yo (off-label)]
- Dose: 2.5-7.5 mg PO tid; Start: 2.5 mg PO bid, may incr. to 7.5 mg PO tid over 7 days; Max: 30 mg/day; Info: give 30-45min before meals, last dose before 6pm
- [6 yo and older]
- Dose: 0.3-2 mg/kg/day PO divided bid-tid; Start: 0.3 mg/kg/dose PO bid or 2.5-5 mg PO bid, may incr. by 0.1 mg/kg/dose or 5-10 mg/day q7 days; Max: 2 mg/kg/day up to 60 mg/day; Info: duration 3-5h; give 30-45min before meals, last dose before 6pm
renal dosing
- [not defined]
- renal impairment: not defined
- HD/PD: not defined
hepatic dosing
- [not defined]