isosorbide dinitrate

Adult Dosing .

Dosage forms:  TAB: 5 mg, 10 mg, 20 mg, 30 mg, 40 mg; ER TAB: 40 mg

angina prophylaxis

[IR form]

Dose: 10-40 mg PO bid-tid; Start: 5-20 mg PO bid-tid; Max: 480 mg/day; Info: daily 14h nitrate-free interval recommended

[ER form]

Dose: 40-80 mg ER PO qd-bid; Start: 40 mg ER PO qd; Max: 160 mg/day ER; Info: daily 18h nitrate-free interval recommended

heart failure w/ reduced ejection fraction (off-label)

[40 mg PO tid]

Start: 20 mg PO tid, may incr. dose q2wk; Max: 120 mg/day; Info: give w/ hydralazine

renal dosing

[see below]

renal impairment: no adjustment

HD/PD: not defined

hepatic dosing

[not defined]

Peds Dosing .

Peds dosing is currently unavailable or not applicable for this drug.