Geodon

Adult Dosing .

Dosage forms:  CAP: 20 mg, 40 mg, 60 mg, 80 mg; INJ: 20 mg per mL

schizophrenia

[20 mg PO bid]

Start: 20 mg PO bid; Max: 160 mg/day; Info: may adjust dose q2 days prn; doses >40 mg/day rarely more effective; periodically reassess need for tx; give w/ food; do not open cap; D/C if ANC <1000; consider D/C if unexplained decr. in WBC

bipolar I disorder, manic/mixed

[monotherapy]

Dose: 40-80 mg PO bid; Start: 40 mg PO bid x1 day, then 60-80 mg PO bid; Max: 160 mg/day; Info: for acute tx; may adjust dose q2 days prn; give w/ food; do not open cap; D/C if ANC <1000; consider D/C if unexplained decr. in WBC

[valproate or lithium adjunct]

Dose: 40-80 mg PO bid; Info: for maintenance tx; continue tx at same dose at which pt initially stabilized; periodically reassess need for tx; give w/ food; do not open cap; D/C if ANC <1000; consider D/C if unexplained decr. in WBC

agitation, schizophrenia-associated

[10 mg IM q2h prn]

Alt: 20 mg IM q4h prn; Max: 40 mg/day x3 days; Info: switch to PO ASAP; D/C if ANC <1000; consider D/C if unexplained decr. in WBC

renal dosing

[PO route]

renal impairment: no adjustment

HD: no adjustment; no supplement; PD: not defined

[IM route]

renal impairment: not defined, caution advised; Info: risk of IM vehicle accumulation

HD/PD: not defined

hepatic dosing

[no adjustment]

Peds Dosing .

Dosage forms:  CAP: 20 mg, 40 mg, 60 mg, 80 mg

bipolar I disorder, manic/mixed (off-label)

[10-17 yo, <45 kg]

Dose: 30-40 mg PO bid; Start: 20 mg PO qpm x1 day, then incr. by 20 mg/day PO q2 days; Max: 160 mg/day; Info: give w/ food; do not open cap; D/C if ANC <1000; consider D/C if unexplained decr. in WBC

[10-17 yo, >45 kg]

Dose: 40-80 mg PO bid; Start: 20 mg PO qpm x1 day, then incr. by 20 mg/day PO q2 days; Max: 160 mg/day; Info: give w/ food; do not open cap; D/C if ANC <1000; consider D/C if unexplained decr. in WBC

Tourette syndrome (off-label)

[7-16 yo]

Dose: 20 mg PO bid; Start: 5 mg PO qd x3 days, then incr. to 5 mg PO bid and titrate as tolerated; Max: 40 mg/day; Info: give w/ food; do not open cap; D/C if ANC <1000; consider D/C if unexplained decr. in WBC

renal dosing

[not defined]

renal impairment: consider adult renal dosing for guidance

HD/PD: consider adult renal dosing for guidance

hepatic dosing

[not defined]

hepatic impairment: consider adult hepatic dosing for guidance