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vincristine
generic
Black Box Warnings .
Appropriate Use
give only by individuals experienced w/ vincristine admin; for IV use only, fatal if given intrathecally; vincristine extravasation during IV admin. may cause considerable irritation, if extravasation occurs immediately D/C injection and give remaining dose via another vein; see pkg insert for extravasation mgmt
Intrathecal Use Contraindicated
must label syringes w/ For Intravenous Use Only - Fatal if Given By Other Routes; need immediate neurosurgical intervention after accidental intrathecal admin. to attempt prevention of ascending paralysis leading to death, see pkg insert
Adult Dosing .
Dosage forms: INJ
Special Note
- [formulation clarification]
- Info: not interchangeable w/ liposomal vincristine products; do not substitute on a mg to mg basis
- [uses, dosing may vary]
- Info: refer to institution protocols and pkg insert prior to prescribing for uses and dosing incl. toxicity-related dose adjustments
ALL
- [1.4 mg/m^2/dose IV qwk]
- Info: part of multi-drug chemo regimen
Hodgkin lymphoma
- [1.4 mg/m^2/dose IV qwk]
- Info: part of multi-drug chemo regimen
non-Hodgkin lymphoma
- [1.4 mg/m^2/dose IV qwk]
- Info: part of multi-drug chemo regimen
solid tumors
- [1.4 mg/m^2/dose IV qwk]
- Info: part of multi-drug chemo regimen
renal dosing
- [no adjustment]
- renal impairment: no adjustment
- HD/PD: no adjustment; no supplement
hepatic dosing
- [adjust dose amount]
- bilirubin >3: decr. usual dose by 50%
Peds Dosing .
- Dosage forms: INJ
Special Note
- [uses, dosing may vary]
- Info: refer to institution protocols and pkg insert prior to prescribing for uses and dosing incl. toxicity-related dose adjustments
ALL
- [1.5-2 mg/m^2/dose IV qwk]
- Info: start 0.05 mg/kg/dose IV qwk in pts <10 kg; part of multi-drug chemo regimen
Hodgkin lymphoma
- [1.5-2 mg/m^2/dose IV qwk]
- Info: start 0.05 mg/kg/dose IV qwk in pts <10 kg; part of multi-drug chemo regimen
non-Hodgkin lymphoma
- [1.5-2 mg/m^2/dose IV qwk]
- Info: start 0.05 mg/kg/dose IV qwk in pts <10 kg; part of multi-drug chemo regimen
solid tumors
- [1.5-2 mg/m^2/dose IV qwk]
- Info: start 0.05 mg/kg/dose IV qwk in pts <10 kg; part of multi-drug chemo regimen
infantile hemangioma, life-threatening (off-label)
- [0.05-1.5 mg/m^2/dose IV x1 q1-3wk x3-4 doses]
- Info: for adjunct tx; use w/ corticosteroid
renal dosing
- [no adjustment]
- renal impairment: no adjustment
- HD/PD: no adjustment; no supplement
hepatic dosing
- [adjust dose amount]
- bilirubin >3: decr. usual dose by 50%