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ketoprofen
generic
Black Box Warnings .
Cardiovascular Thrombotic Event
NSAIDs incr. risk of serious and potentially fatal cardiovascular thrombotic events, incl. MI and stroke; risk may occur early in tx and may incr. w/ duration of use; contraindicated in CABG periop setting
GI Bleeding, Ulceration, and Perforation
NSAIDs incr. risk of serious and potentially fatal GI adverse events incl. bleeding, ulcer, and stomach or intestine perforation; GI events may occur at any time during use and w/o warning sx; elderly pts and pts w/ hx of PUD or GI bleeding at greater risk for serious GI events
Adult Dosing .
Dosage forms: CAP: 50 mg, 75 mg; ER CAP: 200 mg
pain, mild-moderate
- [50 mg PO q6-8h]
- Max: 300 mg/day; Info: use lowest effective dose, shortest effective tx duration; give w/ food if GI upset occurs
osteoarthritis
- [75 mg PO tid]
- Alt: 50 mg PO qid; 200 mg ER PO qd; Max: 300 mg/day; 200 mg/day ER; Info: use lowest effective dose, shortest effective tx duration; give w/ food if GI upset occurs
rheumatoid arthritis
- [75 mg PO tid]
- Alt: 50 mg PO qid; 200 mg ER PO qd; Max: 300 mg/day; 200 mg/day ER; Info: use lowest effective dose, shortest effective tx duration; give w/ food if GI upset occurs
dysmenorrhea
- [50 mg PO q6-8h]
- Max: 300 mg/day; Info: use lowest effective dose, shortest effective tx duration; give w/ food if GI upset occurs
for anti-inflammatory uses (off-label)
- [50-100 mg PO tid x7-14 days]
- Max: 300 mg/day; Info: use lowest effective dose, shortest effective tx duration; give w/ food if GI upset occurs
renal dosing
- [IR form]
- CrCl 60-89: max 150 mg/day; CrCl 25-59: not defined, caution advised; CrCl <25: avoid use; Alt: max 100 mg/day; advanced renal dz: avoid use
- HD: avoid use; Alt: max 100 mg/day; no supplement after dialysis; PD: avoid use; Alt: max 100 mg/day; no supplement
- [ER form]
- renal impairment: avoid use, dose adjustment not possible w/ ER cap; advanced renal dz: avoid use
- HD/PD: avoid use
hepatic dosing
- [adjust dose amount]
- hepatic impairment: max 100 mg/day
Peds Dosing .
Peds dosing is currently unavailable or not applicable for this drug.