metoprolol tartrate

Adult Dosing .

Dosage forms:  TAB: 25 mg, 37.5 mg, 50 mg, 75 mg, 100 mg; INJ: various

HTN

[50-100 mg PO bid]

Start: 50 mg PO bid, may incr. dose qwk; Max: 450 mg/day; Info: give w/ food; taper dose over 1-2wk to D/C; use same total daily dose if switching to extended-release form

angina

[50-200 mg PO bid]

Start: 50 mg PO bid, may incr. dose qwk; Max: 400 mg/day; Info: give w/ food; taper dose over 1-2wk to D/C; use same total daily dose if switching to extended-release form

MI, acute

[100 mg PO bid]

Start: 5 mg IV q2min x3 doses, then after 15min, give 50 mg PO q6h x48h, then incr. to target dose; Info: start 25-50 mg PO q6h if unable to tolerate total IV dose; give PO form w/ food; taper dose over 1-2wk to D/C

cardiovascular event risk reduction, post-MI

[100 mg PO bid]

Start: ASAP after pt stable; Info: give w/ food; taper dose over 1-2wk to D/C

PSVT conversion (off-label)

[2.5-5 mg IV q10min prn up to 3 doses]

Max: 15 mg/total dose

atrial fibrillation/flutter (off-label)

[immediate rate control]

Dose: 2.5-5 mg IV q10min prn up to 3 doses; Max: 15 mg/total dose

[maintenance rate control]

Dose: 25-200 mg PO bid; Start: 25 mg PO bid; Max: 400 mg/day; Info: give w/ food; taper dose over 1-2wk to D/C; use same total daily dose if switching to extended-release form

migraine prophylaxis (off-label)

[25-100 mg PO bid]

Start: 25 mg PO bid, may incr. dose qwk; Max: 200 mg/day; Info: give w/ food; taper dose over 1-2wk to D/C; use same total daily dose if switching to extended-release form

renal dosing

[no adjustment]

renal impairment: no adjustment

HD/PD: no adjustment; no supplement

hepatic dosing

[see below]

hepatic impairment: decr. usual start dose, amount not defined; Info: titrate gradually

Peds Dosing .

Peds dosing is currently unavailable or not applicable for this drug.