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nadolol
generic
Black Box Warnings .
Avoid Abrupt Cessation
severe angina exacerbation, MI, and ventricular arrhythmias in angina pts after abrupt D/C; taper gradually over 1-2wk and monitor when D/C chronic tx, especially in ischemic heart dz; restart tx even temporarily if angina worsens or acute coronary insufficiency develops; warn pts to avoid tx interruption or D/C w/o MD advice; avoid abrupt D/C in all pts in case of unrecognized CAD
Adult Dosing .
Dosage forms: TAB: 20 mg, 40 mg, 80 mg
HTN
- [40-120 mg PO qd]
- Start: 40 mg PO qd, may incr. by 40-80 mg/day q2-14 days; Max: 320 mg/day; Info: taper dose over 1-2wk to D/C
angina
- [40-80 mg PO qd]
- Start: 40 mg PO qd, may incr. by 40-80 mg/day q3-7 days; Max: 240 mg/day; Info: taper dose over 1-2wk to D/C
ventricular arrhythmia (off-label)
- [60-160 mg PO qd]
- Info: taper dose over 1-2wk to D/C
atrial fibrillation/flutter (off-label)
- [10-240 mg PO qd]
- Start: 40 mg PO qd; Max: 320 mg/day; Info: for maintenance rate control; taper dose over 1-2wk to D/C
migraine prophylaxis (off-label)
- [80-160 mg PO qd]
- Start: 40-80 mg PO qd, titrate slowly; Max: 240 mg/day; Info: taper dose over 1-2wk to D/C
renal dosing
- [adjust dose frequency]
- CrCl 31-50: give usual dose q24-36h; CrCl 10-30: give usual dose q24-48h; CrCl <10: give usual dose q40-60h
- HD: give usual dose 3x/wk, on dialysis days admin. after dialysis; no supplement; PD: give usual dose q40-60h; supplement not defined
hepatic dosing
- [not defined]
Peds Dosing .
- Dosage forms: TAB: 20 mg, 40 mg, 80 mg
ventricular arrhythmia (off-label)
- [0.5-1 mg/kg/dose PO qd]
- Max: 2.5 mg/kg/day; Info: taper dose over 1-2wk to D/C
renal dosing
- [not defined]
- renal impairment: consider adult renal dosing for guidance
- HD/PD: consider adult renal dosing for guidance
hepatic dosing
- [not defined]