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fenoprofen
generic
Black Box Warnings .
Cardiovascular Thrombotic Event
NSAIDs incr. risk of serious and potentially fatal cardiovascular thrombotic events, incl. MI and stroke; risk may occur early in tx and may incr. w/ duration of use; contraindicated in CABG periop setting
GI Bleeding, Ulceration, and Perforation
NSAIDs incr. risk of serious and potentially fatal GI adverse events incl. bleeding, ulcer, and stomach or intestine perforation; GI events may occur at any time during use and w/o warning sx; elderly pts and pts w/ hx of PUD or GI bleeding at greater risk for serious GI events
Adult Dosing .
Dosage forms: CAP: 200 mg, 400 mg; TAB: 600 mg
osteoarthritis
- [400-600 mg PO tid-qid]
- Max: 3200 mg/day; Info: use lowest effective dose, shortest effective tx duration; give w/ food if GI upset occurs
rheumatoid arthritis
- [400-600 mg PO tid-qid]
- Max: 3200 mg/day; Info: use lowest effective dose, shortest effective tx duration; give w/ food if GI upset occurs
pain, mild-moderate
- [200 mg PO q4-6h prn]
- Info: use lowest effective dose, shortest effective tx duration; give w/ food if GI upset occurs
for anti-inflammatory uses (off-label)
- [300-600 mg PO tid-qid]
- Info: use lowest effective dose, shortest effective tx duration; give w/ food if GI upset occurs
renal dosing
- [see below]
- CrCl >60: no adjustment; CrCl 30-60: not defined, caution advised; CrCl <30: avoid use; advanced renal dz: avoid use
- HD/PD: avoid use
hepatic dosing
- [see below]
- mild-moderate impairment: not defined, caution advised; significant impairment: avoid use
Peds Dosing .
Peds dosing is currently unavailable or not applicable for this drug.