argatroban

Adult Dosing .

Dosage forms:  INJ

anticoagulation

[individualize dose IV]

Start: 2 mcg/kg/min IV; Max: 10 mcg/kg/min; Info: for pts w/ HIT/HITT; adjust dose to target aPTT 1.5-3x baseline up to 100sec

anticoagulation, PCI adjunct

[15-30 mcg/kg/min IV]

Start: 350 mcg/kg/dose IV x1, then 25 mcg/kg/min IV; Info: for pts w/ or at risk for HIT/HITT; if ACT <300sec after initial bolus, give 150 mcg/kg/dose IV x1, then incr. dose to 30 mcg/kg/min IV; if ACT >450sec after initial bolus, decr. dose to 15 mcg/kg/min IV; adjust dose to target ACT 300-450sec

renal dosing

[see below]

renal impairment: no adjustment

HD: no adjustment; no supplement; PD: not defined

hepatic dosing

[anticoagulation]

Child-Pugh Class A: consider decr. usual start dose; Child-Pugh Class B or C: start 0.5 mcg/kg/min; Info: titrate slowly

[anticoagulation, PCI adjunct]

hepatic impairment: consider decr. usual start dose, titrate slowly; hepatic dz or AST/ALT >3x ULN: avoid use

Peds Dosing .

Dosage forms:  INJ

anticoagulation (off-label)

[0.75 mcg/kg/min IV]

Info: for seriously ill pts w/ HIT/HITT; adjust dose to target aPTT 1.5-3x baseline up to 100sec; may adjust dose by increments of 0.1-0.25 mcg/kg/min IV

renal dosing

[not defined]

renal impairment: consider adult renal dosing for guidance

HD/PD: consider adult renal dosing for guidance

hepatic dosing

[adjust dose amount]

hepatic impairment: start 0.2 mcg/kg/min, may adjust dose by no more than 0.05 mcg/kg/min