tenofovir disoproxil

Adult Dosing .

Dosage forms:  TAB: 300 mg

HIV infection

[300 mg PO qd]

hepatitis B infection, chronic

[300 mg PO qd]

HIV post-exposure prophylaxis (off-label)

[300 mg PO qd]

Info: part of multi-drug regimen; refer to HIV Post-Exposure Prophylaxis, Occupational and HIV Post-Exposure Prophylaxis, Nonoccupational tables; give oral pwdr w/ soft food

hepatitis B infection prophylaxis, perinatal transmission (off-label)

[300 mg PO qd]

Start: at 28-32 wk gestation; Info: for pregnant pts w/ HBV DNA >200,000; 1st-line agent; D/C between birth to 3mo postpartum

renal dosing

[see below]

CrCl 30-49: 300 mg q48h; CrCl 10-29: 300 mg q72-96h; CrCl <10: avoid use

HD: 300 mg q7 days, on dialysis days admin. after dialysis; no supplement; PD: not defined

hepatic dosing

[no adjustment]

Peds Dosing .

Dosage forms:  TAB: 300 mg

HIV infection

[2 yo and older, 10-16 kg]

Dose: 8 mg/kg/dose PO qd; Info: use oral pwdr, not avail. as generic; see brand

[2 yo and older, 17-21 kg]

Dose: 8 mg/kg/dose PO qd; Alt: 150 mg PO qd; Info: use oral pwdr or 150 mg tab, not avail. as generic; see brand

[2 yo and older, 22-27 kg]

Dose: 8 mg/kg/dose PO qd; Alt: 200 mg PO qd; Info: use oral pwdr or 200 mg tab, not avail. as generic; see brand

[2 yo and older, 28-34 kg]

Dose: 8 mg/kg/dose PO qd; Alt: 250 mg PO qd; Info: use oral pwdr or 250 mg tab, not avail. as generic; see brand

[2 yo and older, >35 kg]

Dose: 8 mg/kg/dose PO qd; Max: 300 mg/day; Alt: 300 mg PO qd; Info: use oral pwdr, not avail. as generic; see brand

hepatitis B infection, chronic

[2 yo and older, 10-16 kg]

Dose: 8 mg/kg/dose PO qd; Info: use oral pwdr, not avail. as generic; see brand

[2 yo and older, 17-21 kg]

Dose: 8 mg/kg/dose PO qd; Alt: 150 mg PO qd; Info: use oral pwdr or 150 mg tab, not avail. as generic; see brand

[2 yo and older, 22-27 kg]

Dose: 8 mg/kg/dose PO qd; Alt: 200 mg PO qd; Info: use oral pwdr or 200 mg tab, not avail. as generic; see brand

[2 yo and older, 28-34 kg]

Dose: 8 mg/kg/dose PO qd; Alt: 250 mg PO qd; Info: use oral pwdr or 250 mg tab, not avail. as generic; see brand

[2 yo and older, >35 kg]

Dose: 8 mg/kg/dose PO qd; Max: 300 mg/day; Alt: 300 mg PO qd; Info: use oral pwdr, not avail. as generic; see brand

HIV post-exposure prophylaxis, nonoccupational (off-label)

[2-11 yo, 10-16 kg]

Dose: 8 mg/kg/dose PO qd; Info: part of multi-drug regimen; refer to HIV Post-Exposure Prophylaxis, Nonoccupational table; use oral pwdr, not avail. as generic; see brand

[2-11 yo, 17-21 kg]

Dose: 8 mg/kg/dose PO qd; Alt: 150 mg PO qd; Info: part of multi-drug regimen; refer to HIV Post-Exposure Prophylaxis, Nonoccupational table; use oral pwdr or 150 mg tab, not avail. as generic; see brand

[2-11 yo, 22-27 kg]

Dose: 8 mg/kg/dose PO qd; Alt: 200 mg PO qd; Info: part of multi-drug regimen; refer to HIV Post-Exposure Prophylaxis, Nonoccupational table; use oral pwdr or 200 mg tab, not avail. as generic; see brand

[2-11 yo, 28-34 kg]

Dose: 8 mg/kg/dose PO qd; Alt: 250 mg PO qd; Info: part of multi-drug regimen; refer to HIV Post-Exposure Prophylaxis, Nonoccupational table; use oral pwdr or 250 mg tab, not avail. as generic; see brand

[2-11 yo, >35 kg]

Dose: 8 mg/kg/dose PO qd; Max: 300 mg/day; Alt: 300 mg PO qd; Info: part of multi-drug regimen; refer to HIV Post-Exposure Prophylaxis, Nonoccupational table; use oral pwdr, not avail. as generic; see brand

[12 yo and older]

Dose: 300 mg PO qd; Info: part of multi-drug regimen; refer to HIV Post-Exposure Prophylaxis, Nonoccupational table

hepatitis B infection prophylaxis, perinatal transmission (off-label)

[300 mg PO qd]

Start: at 28-32 wk gestation; Info: for pregnant pts w/ HBV DNA >200,000; 1st-line agent; D/C between birth to 3mo postpartum

renal dosing

[not defined]

renal impairment: consider adult renal dosing for guidance

HD/PD: consider adult renal dosing for guidance

hepatic dosing

[no adjustment]