Kineret

Adult Dosing .

Dosage forms:  INJ (pre-filled syringe): 100 mg per 0.67 mL

Special Note, COVID-19

[FDA emergency use authorization (EUA)]

Info: for hospitalized pts w/ confirmed COVID-19, requiring supplemental oxygen, at risk for progression to severe respiratory failure, and likely to have an elevated plasma soluble urokinase plasminogen activator receptor (suPAR); not FDA approved for COVID-19; avail. from Swedish Orphan Biovitrum or authorized distributors at https://kineretrxhcp.com/EUA.php; for clinical trial eligibility and enrollment info, check www.clinicaltrials.gov

[mandatory reporting for EUA]

Info: serious medication errors and adverse events must be reported to FDA MedWatch (www.fda.gov/medwatch/report.htm or 1-800-FDA-1088) and Swedish Orphan Biovitrum (1-866-773-5274)

rheumatoid arthritis, mod-severe

[100 mg SC q24h]

Info: for monotherapy or in combination w/ other anti-rheumatics except TNF blocking agents

neonatal-onset multisystem inflammatory dz

[3-4 mg/kg/dose SC q24h]

Start: 1-2 mg/kg/dose SC q24h, may incr. by 0.5-1 mg/kg/day; Max: 8 mg/kg/day; Info: may divide dose bid

interleukin-1 receptor antagonist deficiency

[1-8 mg/kg/dose SC q24h]

Start: 1-2 mg/kg/dose SC q24h, may incr. by 0.5-1 mg/kg/day; Max: 8 mg/kg/dose

COVID-19

[100 mg SC q24h x10 days]

Info: for hospitalized, SARS-CoV-2-positive pts requiring supplemental oxygen, at risk for progression to severe respiratory failure, and likely to have an elevated plasma suPAR, per FDA EUA

renal dosing

[see below]

CrCl <30: give usual dose q48h

HD/PD: not defined

hepatic dosing

[not defined]

Peds Dosing .

Dosage forms:  INJ (pre-filled syringe): 100 mg per 0.67 mL

neonatal-onset multisystem inflammatory dz

[3-4 mg/kg/dose SC q24h]

Start: 1-2 mg/kg/dose SC q24h, may incr. by 0.5-1 mg/kg/day; Max: 8 mg/kg/day; Info: may divide dose bid

interleukin-1 receptor antagonist deficiency

[1-8 mg/kg/dose SC q24h]

Start: 1-2 mg/kg/dose SC q24h, may incr. by 0.5-1 mg/kg/day; Max: 8 mg/kg/dose

renal dosing

[see below]

CrCl <30: give usual dose q48h

HD/PD: not defined

hepatic dosing

[not defined]