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carboplatin
generic
Black Box Warnings .
Appropriate Use
admin. only under supervision of physician experienced in cancer chemotherapy in adequate medical facility to manage complications
Serious Adverse Events
dose-related myelosuppression may be severe, causing infection and/or bleeding; anemia may be cumulative and require transfusion support; vomiting occurs frequently
Anaphylaxis
may occur w/in minutes of admin; use epinephrine, corticosteroids, and antihistamines to alleviate sx
Adult Dosing .
Dosage forms: INJ
Special Note
- [uses, dosing may vary]
- Info: refer to institution protocols and pkg insert prior to prescribing for uses, premeds, and dosing incl. toxicity-related dose adjustments
- [dosing clarification]
- Info: use max GFR 125 mL/min in Calvert formula if estimated based on Cr measured by IDMS method; use measured value if actual GFR obtained; refer to institution protocols for target AUC
ovarian CA, advanced
- [monotherapy]
- Dose: 360 mg/m^2/dose IV x1 on day 1 of 28-day cycle; Alt: Calvert formula dose (mg) = target AUC x (GFR + 25) IV x1 on day 1 of 28-day cycle; Info: use Calvert formula dosing in elderly pts
- [combo tx]
- Dose: 300 mg/m^2/dose IV x1 on day 1 of 28-day cycle; Alt: Calvert formula dose (mg) = target AUC x (GFR + 25) IV x1 on day 1 of 28-day cycle; Info: give x6 cycles; use w/ cyclophosphamide; use Calvert formula dosing in elderly pts
renal dosing
- [adjust dose amount]
- CrCl 10-50: decr. usual BSA-based dose by 50%; CrCl <10: decr. usual BSA-based dose by 75%; Alt: use Calvert formula dose (mg) = target AUC x (GFR + 25) to calculate each dose
- HD: decr. usual BSA-based dose by 50%, on dialysis days admin. after dialysis; no supplement; PD: decr. usual BSA-based dose by 75%; no supplement
hepatic dosing
- [not defined]
Peds Dosing .
Peds dosing is currently unavailable or not applicable for this drug.