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perphenazine
generic
Black Box Warnings .
Dementia-Related Psychosis
not approved for dementia-related psychosis; incr. mortality risk in elderly pts on antipsychotic tx for dementia-related psychosis; most deaths due to cardiovascular or infectious events
Adult Dosing .
Dosage forms: TAB: 2 mg, 4 mg, 8 mg, 16 mg
schizophrenia
- [8-16 mg PO bid-qid]
- Start: 4-8 mg PO tid in outpatient; Max: 64 mg/day; Info: use lower start doses in elderly pts; use lowest effective dose; D/C if ANC <1000; consider D/C if unexplained decr. in WBC
nausea/vomiting, severe
- [8-16 mg/day PO divided bid-qid]
- Max: 24 mg/day; Info: use lower start doses in elderly pts; use lowest effective dose; D/C if ANC <1000; consider D/C if unexplained decr. in WBC
renal dosing
- [see below]
- renal impairment: not defined, caution advised
- HD/PD: not defined, caution advised
hepatic dosing
- [see below]
- hepatic impairment: contraindicated
Peds Dosing .
Peds dosing is currently unavailable or not applicable for this drug.