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Black Box Warnings .
Smoking and Cardiovascular Events
cigarette smoking incr. risk of serious cardiovascular events from combined hormonal contraceptive use; incr. risk w/ age (particularly for women >35 yo) and w/ number of cigarettes smoked; contraindicated in smokers >35 yo
Adult Dosing .
Dosage forms: RING: 0.12 mg/0.015 mg per day
contraception
- [1 ring PV x3wk, off x1wk]
- Start: day 1 of menstrual cycle; may start on days 2-5 of menstrual cycle if barrier method used x7days; start w/in 5 days after 1st trimester abortion or miscarriage, >4wk after 2nd trimester abortion or miscarriage, >4wk postpartum if not breastfeeding, or >6wk postpartum if breastfeeding; Info: D/C >4wk before, restart >2wk after surgery w/ VTE risk; use barrier method x7 days if starting postpartum
renal dosing
- [see below]
- renal dz: not defined, caution advised
- HD/PD: avoid use
hepatic dosing
- [see below]
- active hepatic dz: contraindicated
Peds Dosing .
- Dosage forms: RING: 0.12 mg/0.015 mg per day
contraception
- [postmenarchal females]
- Dose: 1 ring PV x3wk, off x1wk; Start: day 1 of menstrual cycle; may start on days 2-5 of menstrual cycle if barrier method used x7days; start w/in 5 days after 1st trimester abortion or miscarriage, >4wk after 2nd trimester abortion or miscarriage, >4wk postpartum if not breastfeeding, or >6wk postpartum if breastfeeding; Info: D/C >4wk before, restart >2wk after surgery w/ VTE risk; use barrier method x7 days if starting postpartum
renal dosing
- [see below]
- renal dz: not defined, caution advised
- HD/PD: avoid use
hepatic dosing
- [see below]
- active hepatic dz: contraindicated