Rebif

Adult Dosing .

Dosage forms:  INJ (auto-injector): 22 mcg, 44 mcg; INJ (pre-filled syringe): 22 mcg per 0.5 mL, 44 mcg per 0.5 mL; auto-injector convenience pack; pre-filled syringe convenience pack

Special Note

[auto-injector convenience pack components]

Info: titration pack contains 8.8 mcg auto-injector x6 and 22 mcg auto-injector x6

[pre-filled syringe convenience pack components]

Info: titration pack contains 8.8 mcg per 0.2 mL pre-filled syringe x6 and 22 mcg per 0.5 mL pre-filled syringe x6

multiple sclerosis, relapsing forms

[44 mcg SC 3x/wk]

Start: 8.8 mcg SC 3x/wk x2wk, then 22 mcg SC 3x/wk x2wk, then 44 mcg SC 3x/wk; Alt: start 4.4 mcg SC 3x/wk x2wk, then 11 mcg SC 3x/wk x2wk, then 22 mcg SC 3x/wk; Info: for pts w/ clinically isolated syndrome, relapsing-remitting dz, and active secondary progressive dz; give doses >48h apart

renal dosing

[not defined]

renal impairment: not defined

HD/PD: not defined

hepatic dosing

[see below]

hepatic impairment: not defined, caution advised

Peds Dosing .

Peds dosing is currently unavailable or not applicable for this drug.