Precedex

Adult Dosing .

Dosage forms:  INJ

ICU sedation

[<24h duration]

Dose: 0.2-0.7 mcg/kg/h IV; Info: may start 1 mcg/kg/dose IV x1; consider lower doses in pts >65 yo; titrate to effect; taper dose gradually to D/C

[>24h duration (off-label)]

Dose: 0.15-1.5 mcg/kg/h IV; Info: may start 1 mcg/kg/dose IV x1; consider lower doses in pts >65 yo; titrate to effect; taper dose gradually to D/C

procedural sedation

[non-intubated pts]

Dose: 0.2-1 mcg/kg/h IV; Start: 1 mcg/kg/dose IV x1, then 0.6 mcg/kg/h IV; Info: start 0.5 mcg/kg/dose IV x1 in pts >65 yo or if less invasive procedure; consider lower maint. dose in pts >65 yo; titrate to effect

[awake fiberoptic intubation]

Dose: 0.7 mcg/kg/h IV; Start: 1 mcg/kg/dose IV x1; Info: start 0.5 mcg/kg/dose IV x1 and consider lower maint. dose in pts >65 yo; titrate to effect

renal dosing

[see below]

renal impairment: no adjustment

HD/PD: not defined

hepatic dosing

[see below]

Child-Pugh Class A, B, or C: consider decr. usual dose

Peds Dosing .

Dosage forms:  INJ

procedural sedation

[IV route, 1-23 mo]

Dose: 0.5-1.5 mcg/kg/h IV; Start: 1.5 mcg/kg/dose IV x1, then 1.5 mcg/kg/h IV; Info: for non-invasive procedures in non-intubated pts; titrate to effect

[IV route, 2-17 yo]

Dose: 0.5-1.5 mcg/kg/h IV; Start: 2 mcg/kg/dose IV x1, then 1.5 mcg/kg/h IV; Info: for non-invasive procedures in non-intubated pts; titrate to effect

[IM route (off-label)]

Dose: 1-4.5 mcg/kg/dose IM x1; Info: may repeat w/ lower dose x1 after 10min

[intranasal route (off-label)]

Dose: 1-2 mcg/kg/dose intranasally x1; Info: use injectable form w/ mucosal atomization device; divide dose and give as 1 spray in each nostril x1

ICU sedation (off-label)

[0.2-1 mcg/kg/h IV]

Start: 0.25-2 mcg/kg/dose IV x1; Max: 2 mcg/kg/h; Info: titrate to effect; children <1 yo may require higher infusion rate; taper dose gradually to D/C if prolonged use

renal dosing

[not defined]

renal impairment: consider adult renal dosing for guidance

HD/PD: not defined

hepatic dosing

[not defined]

hepatic impairment: consider adult hepatic dosing for guidance