Select a medication above to begin.
voriconazole
generic
Adult Dosing .
Dosage forms: TAB: 50 mg, 200 mg; SUSP: 40 mg per mL; INJ: various
infections, severe fungal
- [<40 kg]
- Dose: 4 mg/kg/dose IV q12h; Start: 6 mg/kg/dose IV q12h x2 doses; Info: for infections due to S. apiospermum or Fusarium spp; may decr. maint. dose to 3 mg/kg/dose IV q12h if 4 mg/kg/dose IV q12h not tolerable; may switch to 100-150 mg PO q12h after 7 days of IV tx; give PO 1h before or after meal
- [>40 kg]
- Dose: 4 mg/kg/dose IV q12h; Start: 6 mg/kg/dose IV q12h x2 doses; Info: for infections due to S. apiospermum or Fusarium spp; may decr. maint. dose to 3 mg/kg/dose IV q12h if 4 mg/kg/dose IV q12h not tolerable; may switch to 200-300 mg PO q12h after 7 days of IV tx; give PO 1h before or after meal
aspergillosis, invasive
- [<40 kg]
- Dose: 4 mg/kg/dose IV q12h; Start: 6 mg/kg/dose IV q12h x2 doses; Info: may decr. maint. dose to 3 mg/kg/dose IV q12h if 4 mg/kg/dose IV q12h not tolerable; may switch to 100-150 mg PO q12h after 7 days of IV tx; give PO 1h before or after meal
- [>40 kg]
- Dose: 4 mg/kg/dose IV q12h; Start: 6 mg/kg/dose IV q12h x2 doses; Info: may decr. maint. dose to 3 mg/kg/dose IV q12h if 4 mg/kg/dose IV q12h not tolerable; may switch to 200-300 mg PO q12h after 7 days of IV tx; give PO 1h before or after meal
candidemia, non-neutropenic pts
- [<40 kg]
- Dose: 3-4 mg/kg/dose IV q12h; Start: 6 mg/kg/dose IV q12h x2 doses; Info: treat x14 days after sx resolution or last positive culture; may switch to 100-150 mg PO q12h anytime after day 1; give PO 1h before or after meal
- [>40 kg]
- Dose: 3-4 mg/kg/dose IV q12h; Start: 6 mg/kg/dose IV q12h x2 doses; Info: treat x14 days after sx resolution or last positive culture; may switch to 200-300 mg PO q12h anytime after day 1; give PO 1h before or after meal
candidiasis, deep tissue
- [<40 kg]
- Dose: 3-4 mg/kg/dose IV q12h; Start: 6 mg/kg/dose IV q12h x2 doses; Info: treat x14 days after sx resolution or last positive culture; may switch to 100-150 mg PO q12h anytime after day 1; give PO 1h before or after meal
- [>40 kg]
- Dose: 3-4 mg/kg/dose IV q12h; Start: 6 mg/kg/dose IV q12h x2 doses; Info: treat x14 days after sx resolution or last positive culture; may switch to 200-300 mg PO q12h anytime after day 1; give PO 1h before or after meal
candidiasis, esophageal
- [<40 kg]
- Dose: 100 mg PO q12h; Alt: 3 mg/kg/dose IV q12h; Info: treat x14 days minimum and x7 days after sx resolution; give PO 1h before or after meal
- [>40 kg]
- Dose: 200 mg PO q12h; Alt: 3 mg/kg/dose IV q12h; Info: treat x14 days minimum and x7 days after sx resolution; give PO 1h before or after meal
candidiasis, oropharyngeal (off-label)
- [200 mg PO q12h]
- Info: for fluconazole-refractory dz; give 1h before or after meal
endophthalmitis, fungal (off-label)
- [50-100 mcg in 0.1 mL sterile water intravitreally x1]
- Info: part of multi-drug regimen; refer to institution protocol; may repeat q48h
renal dosing
- [PO route]
- renal impairment: no adjustment
- HD/PD: no adjustment; no supplement
- [IV route]
- CrCl <50: avoid use; Info: risk of IV vehicle accumulation
- HD/PD: avoid use; Info: risk of IV vehicle accumulation
hepatic dosing
- [adjust dose amount]
- Child-Pugh Class A or B: decr. usual maint. dose by 50%; Child-Pugh Class C: not defined
Peds Dosing .
- Dosage forms: TAB: 50 mg, 200 mg; SUSP: 40 mg per mL; INJ: various
infections, severe fungal
- [2-14 yo, <50 kg]
- Dose: 8 mg/kg/dose IV q12h; Start: 9 mg/kg/dose IV q12h x2 doses; Info: for infections due to S. apiospermum or Fusarium spp; may switch to 9 mg/kg/dose PO q12h after 7 days of IV tx, max 350 mg PO q12h; give PO 1h before or after meal
- [2-14 yo, >50 kg]
- see Adult Dosing
- [15 yo and older]
- see Adult Dosing
aspergillosis, invasive
- [2-14 yo, <50 kg]
- Dose: 8 mg/kg/dose IV q12h; Start: 9 mg/kg/dose IV q12h x2 doses; Info: may switch to 9 mg/kg/dose PO q12h after 7 days of IV tx, max 350 mg PO q12h; give PO 1h before or after meal
- [2-14 yo, >50 kg]
- see Adult Dosing
- [15 yo and older]
- see Adult Dosing
candidemia, non-neutropenic pts
- [2-14 yo, <50 kg]
- Dose: 8 mg/kg/dose IV q12h; Start: 9 mg/kg/dose IV q12h x2 doses; Info: treat x14 days after sx resolution or last positive culture; may switch to 9 mg/kg/dose PO q12h anytime after day 1, max 350 mg PO q12h; give PO 1h before or after meal
- [2-14 yo, >50 kg]
- see Adult Dosing
- [15 yo and older]
- see Adult Dosing
candidiasis, deep tissue
- [2-14 yo, <50 kg]
- Dose: 8 mg/kg/dose IV q12h; Start: 9 mg/kg/dose IV q12h x2 doses; Info: treat x14 days after sx resolution or last positive culture; may switch to 9 mg/kg/dose PO q12h anytime after day 1, max 350 mg PO q12h; give PO 1h before or after meal
- [2-14 yo, >50 kg]
- see Adult Dosing
- [15 yo and older]
- see Adult Dosing
candidiasis, esophageal
- [2-14 yo, <50 kg]
- Dose: 9 mg/kg/dose PO q12h; Max: 350 mg PO q12h; Alt: 4 mg/kg/dose IV q12h; Info: treat x14 days minimum and x7 days after sx resolution; give PO 1h before or after meal
- [2-14 yo, >50 kg]
- see Adult Dosing
- [15 yo and older]
- see Adult Dosing
endophthalmitis, fungal (off-label)
- [2 yo and older]
- Dose: 50-100 mcg in 0.1 mL sterile water intravitreally x1; Info: part of multi-drug regimen; refer to institution protocol; may repeat q48h
renal dosing
- [PO route]
- renal impairment: no adjustment
- HD/PD: no adjustment; no supplement
- [IV route]
- CrCl <50: avoid use; Info: risk of IV vehicle accumulation
- HD/PD: avoid use; Info: risk of IV vehicle accumulation
hepatic dosing
- [not defined]
- hepatic impairment: consider adult hepatic dosing for guidance