pyrazinamide

Adult Dosing .

Dosage forms:  TAB: 500 mg

tuberculosis, active

[40-55 kg]

Dose: 1000 mg PO qd x2mo; Alt: 1000 mg PO 5x/wk x2mo if directly observed tx; 1500 mg PO 3x/wk or 2000 mg PO 2x/wk x2mo if directly observed tx; Info: use lean body wt; refer to Lean Body Weight (Female) and Lean Body Weight (Male) calculators; part of multi-drug regimen

[56-75 kg]

Dose: 1500 mg PO qd x2mo; Alt: 1500 mg PO 5x/wk x2mo if directly observed tx; 2500 mg PO 3x/wk or 3000 mg PO 2x/wk x2mo if directly observed tx; Info: use lean body wt; refer to Lean Body Weight (Female) and Lean Body Weight (Male) calculators; part of multi-drug regimen

[76-90 kg]

Dose: 2000 mg PO qd x2mo; Alt: 2000 mg PO 5x/wk x2mo if directly observed tx; 3000 mg PO 3x/wk or 4000 mg PO 2x/wk x2mo if directly observed tx; Info: use lean body wt; refer to Lean Body Weight (Female) and Lean Body Weight (Male) calculators; part of multi-drug regimen

renal dosing

[adjust dose amount, frequency]

CrCl <30: 25-35 mg/kg/dose 3x/wk

HD: 25-35 mg/kg/dose 3x/wk after dialysis; consider supplement if next maint. dose not due right after dialysis; PD: no adjustment; no supplement

hepatic dosing

[see below]

severe impairment: contraindicated

Peds Dosing .

Dosage forms:  TAB: 500 mg

tuberculosis, active

[2 yo and older, <40 kg]

Dose: 30-40 mg/kg/dose PO qd x2mo; Max: 2 g/day; Alt: 30-40 mg/kg/dose PO 5x/wk x2mo if directly observed tx; 50 mg/kg/dose PO 2x/wk x2mo if directly observed tx, max 2 g/dose; Info: use lean body wt; refer to Lean Body Weight (Female) and Lean Body Weight (Male) calculators; part of multi-drug regimen

[2 yo and older, 40-55 kg]

Dose: 1000 mg PO qd x2mo; Alt: 1000 mg PO 5x/wk x2mo if directly observed tx; 1500 mg PO 3x/wk or 2000 mg PO 2x/wk x2mo if directly observed tx; Info: use lean body wt; refer to Lean Body Weight (Female) and Lean Body Weight (Male) calculators; part of multi-drug regimen

[2 yo and older, 56-75 kg]

Dose: 1500 mg PO qd x2mo; Alt: 1500 mg PO 5x/wk x2mo if directly observed tx; 2500 mg PO 3x/wk or 3000 mg PO 2x/wk x2mo if directly observed tx; Info: use lean body wt; refer to Lean Body Weight (Female) and Lean Body Weight (Male) calculators; part of multi-drug regimen

[2 yo and older, 76-90 kg]

Dose: 2000 mg PO qd x2mo; Alt: 2000 mg PO 5x/wk x2mo if directly observed tx; 3000 mg PO 3x/wk or 4000 mg PO 2x/wk x2mo if directly observed tx; Info: use lean body wt; refer to Lean Body Weight (Female) and Lean Body Weight (Male) calculators; part of multi-drug regimen

renal dosing

[adjust dose amount, frequency]

CrCl <30: 40 mg/kg/dose 3x/wk

HD: 40 mg/kg/dose 3x/wk after dialysis; consider supplement if next maint. dose not due right after dialysis; PD: 40 mg/kg/dose 3x/wk; no supplement

hepatic dosing

[see below]

severe impairment: contraindicated