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timolol
generic
Black Box Warnings .
Avoid Abrupt Cessation
severe angina exacerbation, MI, and ventricular arrhythmias in angina pts after abrupt D/C; taper gradually over 1-2wk and monitor when D/C chronic tx, especially in ischemic heart dz; restart tx even temporarily if angina worsens or acute coronary insufficiency develops; warn pts to avoid tx interruption or D/C w/o MD advice; avoid abrupt D/C in all pts in case of unrecognized CAD
Adult Dosing .
Dosage forms: TAB: 5 mg, 10 mg, 20 mg
HTN
- [10-20 mg PO bid]
- Start: 10 mg PO bid, may incr. dose q7 days; Max: 60 mg/day; Info: taper dose over 1-2wk to D/C
cardiovascular event risk reduction, post-MI
- [10 mg PO bid]
- Start: w/in 4wk of MI; Info: taper dose over 1-2wk to D/C
migraine prophylaxis
- [10-30 mg/day PO divided qd-bid]
- Start: 10 mg PO bid; Max: 20 mg/dose, 30 mg/day; Info: D/C if no response in 6-8wk; taper dose over 1-2wk to D/C
angina (off-label)
- [10-60 mg/day PO divided bid-tid]
- Start: 10 mg PO bid; Info: taper dose over 1-2wk to D/C
renal dosing
- [see below]
- renal impairment: consider decr. usual dose
- HD/PD: not defined, caution advised w/ doses >20 mg
hepatic dosing
- [see below]
- hepatic impairment: consider decr. usual dose
Peds Dosing .
Peds dosing is currently unavailable or not applicable for this drug.