trimethoprim

Adult Dosing .

Dosage forms:  TAB: 100 mg

UTI, uncomplicated

[100 mg PO q12h x10-14 days]

Alt: 200 mg PO q24h x10-14 days

UTI prophylaxis (off-label)

[100 mg PO qhs x6-24wk]

Info: not 1st-line tx; high recurrence rates due to TMP-resistance

PCP tx, mild-mod. (off-label)

[15 mg/kg/day PO divided tid x21 days]

Info: give w/ dapsone

renal dosing

[see below]

CrCl 15-30: decr. usual dose by 50%; CrCl <15: avoid use

HD: 100 mg q24h, on dialysis days admin. after dialysis; consider supplement if next maint. dose not due right after dialysis; PD: 100 mg q24h; no supplement

hepatic dosing

[see below]

hepatic impairment: not defined, caution advised

Peds Dosing .

Dosage forms:  TAB: 100 mg

UTI, uncomplicated (off-label)

[2 mo-12 yo]

Dose: 4-6 mg/kg/day PO divided q12h x10-14 days; Info: efficacy as monotherapy not estab. in this age group

[13 yo and older]

Dose: 100 mg PO q12h x10-14 days; Alt: 200 mg PO q24h x10-14 days

UTI prophylaxis (off-label)

[13 yo and older]

Dose: 100 mg PO qhs x6-24wk; Info: not 1st-line tx; high recurrence rates due to TMP-resistance

renal dosing

[not defined]

renal impairment: consider adult renal dosing for guidance

HD/PD: consider adult renal dosing for guidance

hepatic dosing

[see below]

hepatic impairment: not defined, caution advised