atropine

Adult Dosing .

Dosage forms:  INJ (pre-filled syringe): 0.05 mg per mL, 0.1 mg per mL; INJ (vial): 0.4 mg per mL, 1 mg per mL

ACLS, bradycardia

[0.5-1 mg IV q3-5min prn]

Max: 3 mg/total dose; Info: see ACLS: Bradycardia table

anesthesia adjunct

[antisialogogue]

Dose: 0.5-1 mg SC/IM/IV q4-6h prn; Max: 3 mg/total dose; Info: give 1st dose 30-60min preop; 0.03-0.04 mg/kg/max total dose for pts w/ CAD

neuromuscular blockade reversal adjunct

[0.6-1.2 mg IV for each 0.5-2.5 mg neostigmine or 10-20 mg pyridostigmine dose]

Info: admin. w/ or just prior to cholinesterase inhibitor if bradycardia; 0.03-0.04 mg/kg/max total dose for pts w/ CAD

organophosphate nerve agent poisoning

[2 mg IM q5-10min prn]

Start: 2-4 mg IM x1 for mild/moderate sx, 6 mg IM x1 for severe sx; Info: cont. atropinization until muscarinic sx gone; give atropine first if also using pralidoxime (2-PAM); for frail/elderly pts start 1 mg IM x1 for mild/moderate sx, 2-4 mg IM x1 for severe sx

organophosphate or carbamate insecticide poisoning

[individualize dose IV q3-5min prn]

Start: 1-3 mg IV x1, then may double dose q3-5min prn; Info: may give 10-20% loading dose/h IV infusion once pt stabilized; cont. atropinization until muscarinic sx gone; give atropine first if also using pralidoxime (2-PAM)

renal dosing

[not defined]

renal impairment: not defined

HD/PD: not defined

hepatic dosing

[not defined]

Peds Dosing .

Dosage forms:  INJ (pre-filled syringe): 0.05 mg per mL, 0.1 mg per mL; INJ (vial): 0.4 mg per mL, 1 mg per mL

PALS, bradycardia

[0.02 mg/kg/dose IV/IO x1]

Max: 0.5 mg/dose, 1 mg/total dose; Alt: 0.04-0.06 mg/kg/dose ETT x1; Info: for pts w/ incr. vagal tone or primary AV block; may repeat dose x1; IV/IO preferred to ETT route; see PALS: Bradycardia table

anesthesia adjunct

[antisialogogue, <12 yo]

Dose: 0.02 mg/kg/dose SC/IM/IV q4-6h prn; Max: 0.5 mg/dose; 1 mg/procedure; Info: give 1st dose 30-60min preop

[antisialogogue, >12 yo]

Dose: 0.02 mg/kg/dose SC/IM/IV q4-6h prn; Max: 1 mg/dose; 2 mg/procedure; Info: give 1st dose 30-60min preop

neuromuscular blockade reversal adjunct

[0.02 mg/kg/dose IV for each 0.04 mg/kg neostigmine dose]

Info: admin. w/ or just prior to cholinesterase inhibitor if bradycardia

organophosphate nerve agent poisoning

[<2 yo]

Dose: 0.05 mg/kg/dose IM q5-10min prn; Start: 0.05 mg/kg/dose IM x1 for mild/moderate sx, 0.1 mg/kg/dose IM for severe sx; Info: cont. atropinization until muscarinic sx gone; give atropine first if also using pralidoxime (2-PAM)

[2-10 yo]

Dose: 1 mg IM q5-10min prn; Start: 1 mg IM x1 for mild/moderate sx, 2 mg IM x1 for severe sx; Info: cont. atropinization until muscarinic sx gone; give atropine first if also using pralidoxime (2-PAM)

[>10 yo]

Dose: 2 mg IM q5-10min prn; Start: 2 mg IM x1 for mild/moderate sx, 4 mg IM x1 for severe sx; Info: cont. atropinization until muscarinic sx gone; give atropine first if also using pralidoxime (2-PAM)

organophosphate or carbamate insecticide poisoning

[individualize dose IV q3-5min prn]

start: 0.02 mg/kg/dose IV x1, then may double dose q3-5min prn; Info: may give 10-20% loading dose/h IV infusion once pt stabilized; cont. atropinization until muscarinic sx gone; give atropine first if also using pralidoxime (2-PAM)

renal dosing

[not defined]

renal impairment: not defined

HD/PD: not defined

hepatic dosing

[not defined]