lactulose

Adult Dosing .

Dosage forms:  PWDR: 10 g per pkt, 20 g per pkt; SOL: 10 g per 15 mL

constipation

[oral solution form]

Dose: 15-30 mL (10-20 g) PO qd; Info: may incr. dose to 60 mL (40 g) PO qd; response may require 24-48h

[powder form]

Dose: 10-20 g PO qd; Info: may incr. dose to 40 g PO qd; response may require 24-48h

hepatic encephalopathy

[oral solution form]

Dose: 30-45 mL (20-30 g) PO tid-qid; Alt: 300 mL diluted w/ 700 mL NS or water as 30-60min retention enema q4-6h; Info: adjust dose to produce 2-3 soft stools/day; for acute episodes give 30-45 mL (20-30 g) PO q1-2h until 2-3 soft stools/day

renal dosing

[not defined]

renal impairment: not defined

HD/PD: not defined

hepatic dosing

[not defined]

Peds Dosing .

Dosage forms:  SOL: 10 g per 15 mL

hepatic encephalopathy

[infants]

Dose: 2.5-10 mL/day (1.7-6.7 g/day) PO divided tid-qid; Info: adjust dose to produce 2-3 soft stools/day

[children/adolescents]

Dose: 40-90 mL/day (26.7-60 g/day) PO divided tid-qid; Info: adjust dose to produce 2-3 soft stools/day

constipation (off-label)

[1-3 mL/kg/day (0.7-2 g/kg/day) PO divided qd-bid]

Max: 60 mL/day (40 g/day); Info: response may require 24-48h

renal dosing

[not defined]

renal impairment: not defined

HD/PD: not defined

hepatic dosing

[not defined]