Select a medication above to begin.
naloxone
generic
Adult Dosing .
Dosage forms: INJ (auto-injector): 10 mg; INJ (cartridge): 0.4 mg per mL; INJ (pre-filled syringe): 1 mg per mL; INJ (vial): various
opioid overdose
- [IV/IM/SC route]
- Dose: 0.4-2 mg IV/IM/SC q2-3min prn; Alt: 0.67x effective initial bolus dose per hour continuous IV; Info: IV route preferred; reassess tx if no response after 10 mg
- [intranasal route (off-label)]
- Dose: 1 mg in each nostril x1; Info: use injectable form w/ mucosal atomization device; may repeat dose q3-5min prn if sx recur
- [ETT route (off-label)]
- Dose: 0.8-5 mg ETT q2-3min prn
weaponized high-potency opioid overdose
- [auto-injector form]
- Dose: 10 mg SC/IM x1; Info: for use by military personnel and chemical incident responders in pts w/ known or suspected exposure; may repeat dose prn until pt responsive or EMS arrives
weaponized high-potency opioid pre-exposure prophylaxis
- [auto-injector form]
- Dose: 10 mg SC/IM x1; Info: for use by military personnel and chemical incident responders before entering contaminated area; may repeat dose prn if prolonged exposure
opioid reversal, full
- [0.4-2 mg IV/IM/SC q2-3min prn]
- Alt: 0.67x effective initial bolus dose per hour continuous IV; Info: may repeat q1-2h if sx recur; IV route preferred
opioid reversal, partial
- [0.1-0.2 mg IV/IM/SC q2-3min prn]
- Alt: 0.67x effective initial bolus dose per hour continuous IV; Info: may repeat q1-2h if sx recur; IV route preferred
opioid dependence, naloxone challenge test (off-label)
- [IV route]
- Dose: 0.8 mg IV in 2 divided doses; Info: for pts w/ suspected risk of withdrawal prior to naltrexone tx; give 0.2 mg IV x1, if no withdrawal sx after 30sec, then give remaining 0.6 mg IV x1; if positive for withdrawal after 20min from last dose; do not initiate naltrexone; may repeat challenge in 24-48h
- [SC route]
- Dose: 0.8 mg SC x1; Info: for pts w/ suspected risk of withdrawal prior to naltrexone tx; if positive for withdrawal after 20min from dose, do not initiate naltrexone; may repeat challenge in 24-48h
- [IM route]
- Dose: 1.2 mg IM in 2 divided doses; Info: for pts w/ suspected risk of withdrawal prior to naltrexone tx; give 0.4 mg IM x1, if no withdrawal sx after 20min, then give remaining 0.8 mg IM x1; if positive for withdrawal after 20min from last dose, do not initiate naltrexone; may repeat challenge in 24-48h
renal dosing
- [see below]
- renal impairment: no adjustment
- HD/PD: not defined
hepatic dosing
- [not defined]
Peds Dosing .
- Dosage forms: INJ (auto-injector): 10 mg; INJ (cartridge): 0.4 mg per mL; INJ (pre-filled syringe): 1 mg per mL; INJ (vial): various
opioid overdose
- [IV/IM route, <1 mo]
- Dose: 0.1 mg/kg/dose IV/IM q2-3min prn; Alt: 0.67-1x effective initial bolus dose per hour continuous IV; Info: IV route preferred
- [IV/IM/SC route, 1 mo-5 yo and <20 kg]
- Dose: 0.1 mg/kg/dose IV/IM/SC q2-3min prn; Alt: 0.67-1x effective initial bolus dose per hour continuous IV; Info: IV route preferred
- [IV/IM/SC route, >5 yo or >20 kg]
- Dose: 2 mg IV/IM/SC q2-3min prn; Alt: 0.67-1x effective initial bolus dose per hour continuous IV; Info: IV route preferred; reassess tx if no response after 10 mg
- [IO route, 1 mo-5 yo and <20 kg (off-label)]
- Dose: 0.1 mg/kg/dose IO q2-3min prn; Info: IV route preferred
- [IO route, >5 yo or >20 kg (off-label)]
- Dose: 2 mg IO q2-3min prn; Info: IV route preferred
- [ETT route, 1 mo-5 yo and <20 kg (off-label)]
- Dose: 0.2-0.3 mg/kg/dose ETT q2-3min prn; Info: IV route preferred
- [ETT route, >5 yo or >20 kg (off-label)]
- Dose: 4-6 mg ETT q2-3min prn; Info: IV route preferred
weaponized high-potency opioid overdose
- [auto-injector form, 12 yo and older]
- Dose: 10 mg SC/IM x1; Info: for use by military personnel and chemical incident responders in pts w/ known or suspected exposure; may repeat dose prn until pt responsive or EMS arrives
opioid reversal, full
- [<1 mo]
- Dose: 0.01-0.015 mg/kg/dose IV/IM q2-3min prn; Info: may repeat q1-2h if sx recur; IV route preferred
- [1 mo-5 yo and <20 kg]
- Dose: 0.01-0.015 mg/kg/dose IV/IM/SC q2-3min prn; Info: may repeat q1-2h if sx recur; IV route preferred
- [>5 yo or >20 kg]
- Dose: 2 mg IV/IM/SC q2-3min prn; Info: may repeat q1-2h if sx recur; IV route preferred
opioid reversal, partial
- [<1 mo]
- Dose: 0.001-0.01 mg/kg/dose IV/IM q2-3min prn; Info: may repeat q1-2h if sx recur; IV route preferred
- [1 mo and older and <20 kg]
- Dose: 0.001-0.01 mg/kg/dose IV/IM/SC q2-3min prn; Info: may repeat q1-2h if sx recur; IV route preferred
- [>20 kg]
- Dose: 0.1-0.2 mg IV/IM/SC q2-3min prn; Info: may repeat q1-2h if sx recur; IV route preferred
renal dosing
- [see below]
- renal impairment: no adjustment
- HD/PD: not defined
hepatic dosing
- [not defined]