Select a medication above to begin.
Abilify
aripiprazole
Black Box Warnings .
Dementia-Related Psychosis
not approved for dementia-related psychosis; incr. mortality risk in elderly pts on antipsychotic tx for dementia-related psychosis; most deaths due to cardiovascular or infectious events
Suicidality
incr. suicidality risk in children, adolescents, and young adults w/ major depressive or other psychiatric disorders; weigh risk vs. benefit; in short-term studies of antidepressants vs. placebo, suicidality risk not incr. in pts >24 yo, and risk decr. in pts 65 yo and older; depression and certain other psychiatric disorders themselves assoc. w/ incr. suicide risk; observe all pts for clinical worsening, suicidality, or unusual behavior changes; advise families and caregivers of need for close observation and communication w/ prescriber; not approved for depression in peds pts
Adult Dosing .
Dosage forms: TAB: 2 mg, 5 mg, 10 mg, 15 mg, 20 mg, 30 mg
schizophrenia
- [10-15 mg PO qd]
- Start: 10-15 mg PO qd; may incr. dose q2wk; Max: 30 mg/day; Info: doses >15 mg/day rarely more effective; decr. dose 50% in CYP2D6 poor metabolizers; periodically reassess need for tx; D/C if ANC <1000; consider D/C if unexplained decr. in WBC
bipolar I disorder, manic/mixed
- [monotherapy]
- Dose: 15 mg PO qd; Max: 30 mg/day; Info: for acute and maintenance tx; decr. dose 50% in CYP2D6 poor metabolizers; periodically reassess need for tx; D/C if ANC <1000; consider D/C if unexplained decr. in WBC
- [valproate or lithium adjunct]
- Dose: 15 mg PO qd; Start: 10-15 mg PO qd; Max: 30 mg/day; Info: for acute and maintenance tx; decr. dose 50% in CYP2D6 poor metabolizers; periodically reassess need for tx; D/C if ANC <1000; consider D/C if unexplained decr. in WBC
major depressive disorder, adjunct tx
- [2-15 mg PO qd]
- Start: 2-5 mg PO qd, may incr. by up to 5 mg/day qwk; Max: 15 mg/day; Info: periodically reassess need for tx; D/C if ANC <1000; consider D/C if unexplained decr. in WBC
renal dosing
- [see below]
- CrCl >15: no adjustment; CrCl <15: not defined
- HD/PD: not defined
hepatic dosing
- [no adjustment]
Peds Dosing .
- Dosage forms: TAB: 2 mg, 5 mg, 10 mg, 15 mg, 20 mg, 30 mg
schizophrenia
- [13-17 yo]
- Dose: 10 mg PO qd; Start: 2 mg PO qd x2 days, then 5 mg PO qd x2 days, then incr. dose in 5 mg increments; Max: 30 mg/day; Info: doses >10 mg/day rarely more effective; decr. dose 50% in CYP2D6 poor metabolizers; periodically reassess need for tx; D/C if ANC <1000; consider D/C if unexplained decr. in WBC
bipolar I disorder, manic/mixed
- [10-17 yo]
- Dose: 10 mg PO qd; Start: 2 mg PO qd x2 days, then 5 mg PO qd x2 days, then incr. dose in 5 mg increments; Max: 30 mg/day; Info: for acute and maint. monotherapy or valproate or lithium adjunct; decr. dose 50% in CYP2D6 poor metabolizers; periodically reassess need for tx; D/C if ANC <1000; consider D/C if unexplained decr. in WBC
irritability, autistic disorder-assoc.
- [6-17 yo]
- Dose: 5-10 mg PO qd; Start: 2 mg PO qd x1wk, then 5 mg PO qd, then may incr. by up to 5 mg/day qwk; Max: 15 mg/day; Info: decr. dose 50% in CYP2D6 poor metabolizers; periodically reassess need for tx; D/C if ANC <1000; consider D/C if unexplained decr. in WBC
Tourette syndrome
- [6-18 yo, <50 kg]
- Dose: 5 mg PO qd; Start: 2 mg PO qd x2 days, then 5 mg PO qd; may incr. dose gradually qwk; Max: 10 mg/day; Info: decr. dose 50% in CYP2D6 poor metabolizers; periodically reassess need for tx; D/C if ANC <1000; consider D/C if unexplained decr. in WBC
- [6-18 yo, >50 kg]
- Dose: 10 mg PO qd; Start: 2 mg PO qd x2 days, then 5 mg PO qd x5 days, then 10 mg PO qd; may incr. by 5 mg/day qwk; Max: 20 mg/day; Info: decr. dose 50% in CYP2D6 poor metabolizers; periodically reassess need for tx; D/C if ANC <1000; consider D/C if unexplained decr. in WBC
renal dosing
- [see below]
- CrCl >15: no adjustment; CrCl <15: not defined
- HD/PD: not defined
hepatic dosing
- [no adjustment]