Select a medication above to begin.
atomoxetine
generic
Black Box Warnings .
Suicidality
incr. risk of suicidality in children/adolescents w/ ADHD, esp. during 1st months of tx; weigh risk vs. benefit; co-morbidities occurring w/ ADHD may be assoc. w/ incr. risk of suicidal ideation or behavior; observe closely for clinical worsening, suicidality, or unusual behavior changes; not approved for major depression; avg risk 0.4% w/ atomoxetine vs. none w/ placebo in pooled analyses of short-term use, no suicides in these trials
Adult Dosing .
Dosage forms: CAP: 10 mg, 18 mg, 25 mg, 40 mg, 60 mg, 80 mg, 100 mg
ADHD
- [80 mg/day PO divided qd-bid]
- Start: 40 mg PO qam for at least 3 days; Max: 100 mg/day; Info: may incr. to 100 mg/day after 2-4wk; in CYP2D6 poor metabolizers, start 40 mg PO qam x4wk; do not open cap; periodically reassess need for tx
cataplexy (off-label)
- [40-100 mg/day PO divided qd-bid]
- Start: 20 mg PO qam for at least 3 days; Max: 100 mg/day; Info: may incr. to 100 mg/day after 2-4wk; in CYP2D6 poor metabolizers, start 20 mg PO qam x4wk; do not open cap
renal dosing
- [see below]
- renal impairment: no adjustment
- HD/PD: not defined
hepatic dosing
- [adjust dose amount]
- Child-Pugh Class B: decr. usual start and target dose by 50%; Child-Pugh Class C: decr. usual start and target dose by 75%
Peds Dosing .
- Dosage forms: CAP: 10 mg, 18 mg, 25 mg, 40 mg, 60 mg, 80 mg, 100 mg
ADHD
- [6 yo and older, <70 kg]
- Dose: 1.2 mg/kg/day PO divided qd-bid; Start: 0.5 mg/kg/dose PO qam for at least 3 days; Max: 1.4 mg/kg/day; Info: in CYP2D6 poor metabolizers, start 0.5 mg/kg/dose PO qam x4wk; do not open cap; periodically reassess need for tx
- [6 yo and older, >70 kg]
- Dose: 80 mg/day PO divided qd-bid; Start: 40 mg PO qam for at least 3 days; Max: 100 mg/day; Info: may incr. to 100 mg/day after 2-4wk; in CYP2D6 poor metabolizers, start 40 mg PO qam x4wk; do not open cap; periodically reassess need for tx
cataplexy (off-label)
- [5 yo and older]
- Dose: 10-25 mg PO qd; Start: 10 mg PO qam for at least 3 days; Max: 100 mg/day; Info: may incr. to 100 mg/day after 2-4wk; in CYP2D6 poor metabolizers, start 10 mg PO qam x4wk; do not open cap
renal dosing
- [see below]
- renal impairment: no adjustment
- HD/PD: not defined
hepatic dosing
- [adjust dose amount]
- Child-Pugh Class B: decr. usual start and target dose by 50%; Child-Pugh Class C: decr. usual start and target dose by 75%