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Pegasys
peginterferon alfa 2a
Black Box Warnings .
Fatal/Life-Threatening Events
alpha-interferons can cause or aggravate fatal or life-threatening neuropsychiatric, autoimmune, ischemic, and infectious disorders; closely monitor w/ clinical and lab eval.; D/C tx if persistently severe or worsening s/sx of these conditions; disorders resolve in many but not all cases after D/C tx
Adult Dosing .
Dosage forms: INJ (pre-filled syringe): 180 mcg per 0.5 mL; INJ (vial): 180 mcg per mL
hepatitis B infection, chronic
- [180 mcg SC qwk x48wk]
- Info: see pkg insert for dose adjustments based on toxicities
renal dosing
- [see below]
- CrCl <30: 135 mcg qwk; Info: see pkg insert for dose adjustments based on toxicities
- HD: 135 mcg qwk; no supplement after dialysis; PD: not defined; Info: see pkg insert for dose adjustments based on toxicities
hepatic dosing
- [see below]
- Child-Pugh Class B or C or autoimmune hepatitis: contraindicated
Peds Dosing .
- Dosage forms: INJ (pre-filled syringe): 180 mcg per 0.5 mL; INJ (vial): 180 mcg per mL
hepatitis B infection, chronic
- [3 yo and older]
- Dose: 180 mcg/1.73 m^2 SC qwk x48wk; Max: 180 mcg/dose; Info: see pkg insert for dose adjustments based on toxicities
renal dosing
- [not defined]
- renal impairment: consider adult renal dosing for guidance
- HD/PD: consider adult renal dosing for guidance
hepatic dosing
- [see below]
- Child-Pugh Class B or C or autoimmune hepatitis: contraindicated