etoposide

Adult Dosing .

Dosage forms:  CAP: 50 mg; INJ: various

Special Note

[uses, dosing may vary]

Info: refer to institution protocols and pkg insert prior to prescribing for uses and dosing incl. toxicity-related dose adjustments

testicular CA, refractory

[50-100 mg/m^2/dose IV x1 on days 1-5 of 21-day cycle]

Alt: 100 mg/m^2/dose IV x1 on days 1, 3, 5 of 21-day cycle; Info: part of multi-drug chemo regimen

small cell lung CA

[PO route]

Dose: 70 mg/m^2/dose PO qd on days 1-4 to 100 mg/m^2/dose PO qd on days 1-5 of 21- or 28-day cycle; Info: part of multi-drug chemo regimen; round dose to nearest 50 mg

[IV route]

Dose: 35 mg/m^2/dose IV x1 on days 1-4 to 50 mg/m^2/dose IV x1 on days 1-5 of 21- or 28-day cycle; Info: part of multi-drug chemo regimen

renal dosing

[adjust dose amount]

CrCl 15-50: decr. usual dose by 25%; CrCl <15: decr. usual dose by 50%

HD: decr. usual dose by 50%; no supplement after dialysis; PD: decr. usual dose by 50%; no supplement

hepatic dosing

[not defined]

Peds Dosing .

Peds dosing is currently unavailable or not applicable for this drug.